Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures

NCT ID: NCT03631901

Last Updated: 2019-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-01

Study Completion Date

2018-09-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To evaluate the efficacy of oral melatonin compared to oral diazepam for prevention of recurrent simple febrile seizures.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

To evaluate the efficacy of oral melatonin compared to oral diazepam for prevention of recurrence of simple febrile seizures in children aged 6 months to 5 years.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Febrile Seizures

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Melatonin

melatonin 0.3mg/kg/8 hours, orally. Given only during the febrile illness.

Group Type ACTIVE_COMPARATOR

oral melatonin

Intervention Type DRUG

Both melatonin and diazepam were given only during the febrile illness.

Diazepam

oral diazepam 1mg/kg/day divided into 3 doses. Given only during the febrile illness.

Group Type ACTIVE_COMPARATOR

oral diazepam

Intervention Type DRUG

Both melatonin and diazepam were given only during the febrile illness.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

oral melatonin

Both melatonin and diazepam were given only during the febrile illness.

Intervention Type DRUG

oral diazepam

Both melatonin and diazepam were given only during the febrile illness.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Children aged 6 months to 5 yrs .
* Simple febrile seizures

Exclusion Criteria

* Complex febrile seizures
* Child with history of neonatal seizure.
* Afebrile seizures.
* History of anticonvulsive therapy.
* Children suffering from epilepsy.
* Children with abnormal EEG.
* Children with abnormal neurological examination.
* Positive family history of epilepsy.
Minimum Eligible Age

6 Months

Maximum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Tanta University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Amira Hamed Darwish

Professor of pediatrics and Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Amira Darwish

Role: PRINCIPAL_INVESTIGATOR

Tanta University Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Tanta University, Faculty of Medicine

Tanta, , Egypt

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

TU2017

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Effects of Diazepam on RNS Detections
NCT05273398 COMPLETED PHASE4
Getting SMART for Pediatric Epilepsy
NCT05439876 COMPLETED PHASE2/PHASE3
Study of Midazolam in Healthy Adults
NCT04679623 COMPLETED PHASE1