Trial Outcomes & Findings for Response Inhibition in Tourette Syndrome (NCT NCT03628703)
NCT ID: NCT03628703
Last Updated: 2024-04-18
Results Overview
SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control.
COMPLETED
NA
10 participants
30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task)
2024-04-18
Participant Flow
Participant milestones
| Measure |
Repetitive TMS
Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation
Repetitive TMS: Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area
|
|---|---|
|
Overall Study
STARTED
|
10
|
|
Overall Study
COMPLETED
|
10
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Response Inhibition in Tourette Syndrome
Baseline characteristics by cohort
| Measure |
Repetitive TMS
n=10 Participants
Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation
Repetitive TMS: Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area
|
|---|---|
|
Age, Continuous
|
14.9 years
STANDARD_DEVIATION 3.8 • n=5 Participants
|
|
Sex: Female, Male
Female
|
3 Participants
n=5 Participants
|
|
Sex: Female, Male
Male
|
7 Participants
n=5 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=5 Participants
|
|
Race (NIH/OMB)
White
|
10 Participants
n=5 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
|
Region of Enrollment
United States
|
10 participants
n=5 Participants
|
|
Yale Global Tic Severity Scale
|
19.3 units on a scale
STANDARD_DEVIATION 10.1 • n=5 Participants
|
PRIMARY outcome
Timeframe: 30 minutes after Repetitive Transcranial Magnetic Stimulation (as it takes about 30 minutes to complete the modified Slater-Hammel stop signal task)SSRT measured from modified Slater-Hammel stop signal task performance. The SSRT is calculated by subtracting the average stop signal delay (msec) from the average go-trial reaction time. The SSRT is a measure of inhibitory behavior. The lower the SSRT value means a person is better at inhibitory control. The higher the SSRT value means a person is worse at inhibitory control.
Outcome measures
| Measure |
Repetitive TMS
n=10 Participants
Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation
Repetitive TMS: Repetitive Intermittent Theta-Burst Transcranial Magnetic Stimulation over the right Pre-supplementary Motor Area
|
|---|---|
|
Stop Signal Reaction Time (SSRT)
Before Repetitive TMS
|
249 milliseconds
Standard Deviation 28.0
|
|
Stop Signal Reaction Time (SSRT)
After Repetitive TMS
|
245 milliseconds
Standard Deviation 11.2
|
Adverse Events
Repetitive TMS
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Steve W. Wu, M.D.
Cincinnati Children's Hospital Medical Center
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place