Fixed Dose Triple Therapy in Severe Chronic Obstructive Pulmonary Disease in a Real World Setting

NCT ID: NCT03627858

Last Updated: 2021-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

149 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-08-01

Study Completion Date

2020-08-03

Brief Summary

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The rationale for this non-interventional study in confirmed moderate to severe chronic obstructive pulmonary disease patients aged 40 years and above, is to assess real-life effectiveness and safety of Trimbow® in clinical practice, and to bridge the gap with the existing clinical data.

Detailed Description

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This non-interventional study assesses the real-life effectiveness and safety of the fixed triple therapy Trimbow® compared to free triple therapy, considering patient individual data, in clinical practice at second and thirdline centres in patients with confirmed moderate to severe chronic obstructive pulmonary disease.

This is an hypothesis generating study. No formal primary endpoint is defined; parameters are evaluated in an exploratory or descriptive manner.

Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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beclomethasone / formoterol / glycopyrronium

As this is a non-interventional study, all treatment decisions will be made at the discretion of the treating physician prior to enrolment in the study and during the entire period of the study. Treatment will be prescribed according to the product label in the summary of product characteristics.

Intervention Type DRUG

Other Intervention Names

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Trimbow®

Eligibility Criteria

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Inclusion Criteria

* Patient has provided written informed consent
* Patient is aged 40 years or older at time of initiation of Trimbow® treatment
* Patient is diagnosed with moderate or severe chronic obstructive pulmonary disease confirmed by spirometry (post-bronchodilation) based on the Global Initiative for chronic obstructive lung disease (GOLD) 2018 classification
* Patient treated with double inhalation or free triple therapy (using at least 2 devices) who are prescribed Trimbow®

Exclusion Criteria

• Hypersensitivity to the active substances or to any of the excipients listed below:

* Ethanol anhydrous
* Hydrochloric acid
* Norflurane (propellant)
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chiesi SA/NV

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guy Brusselle, MD-PhD

Role: PRINCIPAL_INVESTIGATOR

University Ghent

Locations

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ZNA Middelheim

Antwerp, , Belgium

Site Status

Universitair Ziekenhuis Antwerpen

Antwerp, , Belgium

Site Status

GZA Campus Sint-Vincentius

Antwerp, , Belgium

Site Status

Hôpital Erasme

Brussels, , Belgium

Site Status

UZ Brussel

Brussels, , Belgium

Site Status

Grand Hôpital de Charleroi

Charleroi, , Belgium

Site Status

Clinique Notre-Dame de Grâce ASBL Gosselies

Charleroi, , Belgium

Site Status

UZ Gent

Ghent, , Belgium

Site Status

AZ Groeninge

Kortrijk, , Belgium

Site Status

CHR de la Citadelle

Liège, , Belgium

Site Status

AZ Sint-Maarten

Mechelen, , Belgium

Site Status

Hôpital André Vésale

Montigny-le-Tilleul, , Belgium

Site Status

Clinique Saint-Luc Bouge

Namur, , Belgium

Site Status

AZ Delta

Roeselare, , Belgium

Site Status

Hospital Center De Wallonie Picarde

Tournai, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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CHIESI_NIS_0001

Identifier Type: -

Identifier Source: org_study_id