Multi-component Intervention for Diabetes in Adults With Serious Mental Illness

NCT ID: NCT03627377

Last Updated: 2021-09-17

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 210 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-12-28
• Study Completion Date: 2022-05-31

Brief Summary

Persons with schizophrenia and other serious mental illnesses have a high risk for type 2 diabetes and an increased risk of premature mortality compared to the general population. The goals of the proposed study are to implement a multimodal lifestyle intervention to reduce that risk in these individuals living in residential care facilities, a common housing modality for people with serious mental illnesses. If successful, this intervention will lead to reduction in excess medical comorbidity and mortality in persons with serious mental illnesses.

Detailed Description

Serious mental illnesses (SMI), including schizophrenia, bipolar disorder, and schizoaffective disorder, are associated with increased medical comorbidity and premature mortality from diabetes and cardiovascular disease. Unhealthy lifestyles, including energy-dense (obesogenic) diet, sedentary behavior, and cigarette smoking are important risk factors for diabetes and accelerated biological aging. All of these risk factors are potentially modifiable. There is considerable literature documenting the effectiveness of strategies to prevent and manage diabetes in the general population; yet, these interventions are rarely offered to people with SMI. Residential Care Facilities (RCFs), called Board-and-Care Homes in California, are a common housing modality for patients with SMI; they provide a venue that can maximize efficiency and sustainability of a lifestyle intervention. The goals of the proposed four-year study are to tailor a multi-component intervention to this high-risk group. The study will be a hybrid effectiveness-implementation (Hybrid Type 1) trial of a Multi-component Intervention for Diabetes risk reduction in Adults with SMI (MIDAS) in licensed RCFs in San Diego county. As a Hybrid Type 1 study, the primary emphasis will be on determining the effectiveness of the intervention to achieve desired health outcomes while also systematically collecting data on its implementation within RCFs that will inform implementation strategy refinement. Main components of MIDAS include: (1) Education about diabetes and lifestyle, (2) Dietary intervention at the facility and resident level, (3) Increased physical activity, and (4) Smoking cessation / reduction. The investigators will employ a modified cluster-randomized stepped wedge and adaptive trial design involving 210 residents with SMI and 120 staff members from 12 RCFs. The RCFs will be divided randomly into four cohorts of three RCFs each. Each cohort will be tested over a 15-month period that includes three phases: a three-month initial control phase (no intervention, from baseline month 0 to end of month 3), a six-month intervention phase (months 4 through 9), and a six-month follow-up phase (no intervention, months 10 through 15). All the study participants will be assessed quarterly during the 15-month period. Our investigators will train RCF staff (especially the Activity Director and cook) to increase physical activity and reduce smoking, and to implement healthful dietary modifications among the residents, using evidence-based interventions. During the intervention phase, the RCF Activity Director will conduct twice-weekly manualized group sessions on education about diabetes, nutrition, exercise, and smoking cessation/reduction, to deliver a multi-component group intervention. We will also explore if there are improvements in blood-based research biomarkers of insulin resistance and inflammation in the RCF residents with SMI. This project is responsive to RFA-MH-17-608, and related to NIMH Strategic Objective #3.3B: testing interventions for effectiveness in community practice settings. If successful, MIDAS will be sustained and disseminated, and would lead to reduction in excess medical comorbidity and mortality associated with SMI.

Conditions

Schizophrenia; Obesity; Diabetes; Lifestyle Risk Reduction; Serious Mental Illness

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Control Phase

3-month initial control phase (no intervention, month 1-3)

Group Type: NO_INTERVENTION

No interventions assigned to this group

Intervention Phase

6-month intervention phase - MIDAS Intervention Delivered. Followed by 6-month follow-up phase (no intervention, months 10-15).

Group Type: EXPERIMENTAL

Multi-component Intervention for Diabetes in Adults with Serious Mental Illness

Intervention Type: BEHAVIORAL

Main components of MIDAS include: (1) Education about diabetes and lifestyle, (2) Dietary intervention at the facility and resident level, (3) Increased physical activity, and (4) Smoking cessation / reduction.

Interventions

Multi-component Intervention for Diabetes in Adults with Serious Mental Illness

Main components of MIDAS include: (1) Education about diabetes and lifestyle, (2) Dietary intervention at the facility and resident level, (3) Increased physical activity, and (4) Smoking cessation / reduction.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. Licensed by California Division of Social Services' Community Care Licensing

2. Serves only individuals with SMI

3. Has >15 residents currently living in the facility

4. Willing to participate

Staff Participants:

1. Age >21 years

2. Fluent in English

3. Written informed consent to participate

1. Age 18 - 65 years

2. Chart diagnosis of an SMI, mainly schizophrenia, schizoaffective disorder, or bipolar disorder

3. Current treatment with antipsychotics

4. Fluent in English

5. Written informed consent to participate in this study

Exclusion Criteria

Residential Care Facilities (RCFs):

(1) Plans to leave the RCF during the next year.

Resident Participants:

1. Chart diagnosis of dementia or intellectual disability disorder

2. Active substance abuse (non-tobacco)

3. Medical problems that interfere with ability to complete assessments and intervention

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of California, San Diego

OTHER

Sponsor Role: lead

Responsible Party

Dilip V. Jeste

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of California, San Diego Division of Geriatric Psychiatry

La Jolla, California, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Dilip V Jeste, MD

Role: CONTACT

djeste@ucsd.edu

(858) 534-4020

Danielle K Glorioso, LCSW

Role: CONTACT

dglorioso@ucsd.edu

(858) 246-0767

Facility Contacts

Danielle K Glorioso, LCSW

Role: primary

dglorioso@ucsd.edu

858-246-0767

Cynthia Ibarra, MA

Role: backup

cyibarra@ucsd.edu

(858) 822-6005

Other Identifiers

MH15127

Identifier Type: -

Identifier Source: org_study_id