Antioxidants vs. Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-06

Study Completion Date

2017-08-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed.

Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve.

The analysis has been made to compare the efficacy of both procedures.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Observational Study to Evaluate Fertility in Women Between 32 and 38 Years Old Treated With the Ovosicare® Fertility

NCT07083999

Fertility

RECRUITING

Effects of Resveratrol Supplementation on Oocyte Quality

NCT06235294

Aging Infertility

NOT_YET_RECRUITING NA

Use of Autologous Exosomes vs Platelet Growth Factors to Regenerate the Ovary in Women With Infertility (Exosomas2024-1)

NCT06773572

Infertility, Female Reproductive Techniques, Assisted

COMPLETED NA

Oxidative Stress-related Gene Expression in Cumulus Cells Among Low Responders

NCT03155438

Low Responder

UNKNOWN

Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation

NCT05279560

Premature Ovarian Insufficiency Infertility, Female Sterility, Female +1 more

ACTIVE_NOT_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ovarian Reserve

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Prospective comparative study

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

ovarian bio-stimulation

Intervention:

ovarian bio-stimulation: blood rich plasma platelets

Group Type EXPERIMENTAL

blood rich plasma platelets

Intervention Type PROCEDURE

Injection of blood rich platelet into the ovaries.

Antioxidant therapy

Intervention Type DIETARY_SUPPLEMENT

Antioxidants:

Q10, DHEA, Vitamina E, Vitamin C, Omega 3

Antioxidant therapy

Intervention:

antioxidants: Q10, DHEA, Vitamin E, Vitamin C, omega 3

Group Type ACTIVE_COMPARATOR

blood rich plasma platelets

Intervention Type PROCEDURE

Injection of blood rich platelet into the ovaries.

Antioxidant therapy

Intervention Type DIETARY_SUPPLEMENT

Antioxidants:

Q10, DHEA, Vitamina E, Vitamin C, Omega 3

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood rich plasma platelets

Injection of blood rich platelet into the ovaries.

Intervention Type PROCEDURE

Antioxidant therapy

Antioxidants:

Q10, DHEA, Vitamina E, Vitamin C, Omega 3

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age between 38 and 46 years
* FSH\> 12 mIU
* Estradiol \> 100 pg/ml
* AMH \< 0.8 ng/mL

Exclusion Criteria

* Pelvic inflammatory syndrome
* vaginal pathologies
* known history of hyperandrogenism
* diagnosed platelet disorders as adhesion
* aggregation
* disorder of thromboxane synthesis.

Minimum Eligible Age

38 Years

Maximum Eligible Age

46 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes