Clinical and Radiographic Evaluation of Indirect Pulp Capping in Primary and Permanent Teeth With Different Materials

NCT ID: NCT03606681

Last Updated: 2018-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-06-30

Brief Summary

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Indirect pulp capping (IPC) is a treatment that preserves pulp's vitality. Several materials have been used for this procedure. The aim of this study is to evaluate the radiographic and clinical outcomes of TheraCal LC (Bisco Inc., Schaumburg, IL, USA) and to compare it with mineral trioxide aggregate (MTA) (Pro Root MTA, Dentsply Tulsa, Johnson City, TN, USA) and calcium hydroxide \[Ca(OH)2\] (Dycal, Dentsply De Trey Konstanz, Germany) biomaterials in IPC treatment.

Detailed Description

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A total of 295 teeth, including second primary molars and first permanent molars with IPC indications from healthy and cooperative children between the ages of 4-15, were included in this study. Teeth were divided into three groups according to the materials used for pulp capping. Indirect pulp treatment was applied using Dycal for 91 teeth, ProRoot MTA for 89 teeth and TheraCal LC for 115 teeth. Primary molars were restored with the compomer material, and permanent molars were restored with the resin composite material. Restorations were evaluated with the Modified United States Public Health Service (modified USPHS) criteria. Clinical and radiographic findings were evaluated for 24 months at follow-up.

Conditions

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Dental Pulp Capping

Keywords

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Dental Pulp calcium hydroxide Dental Pulp Capping

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Calcium Hydroxide (Dycal)

Indirect pulp capping treatment with Calcium Hydroxide

Group Type ACTIVE_COMPARATOR

Calcium Hydroxide

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in the same session.

Mineral Trioxide Aggregate

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in in the same session.

TheraCal LC

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity (2 milimeter layer) and polymerized and restoration was finished in in the same session.

Mineral Trioxide Aggregate (ProRoot MTA)

Indirect pulp capping treatment with Mineral Trioxide Aggregate

Group Type EXPERIMENTAL

Calcium Hydroxide

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in the same session.

Mineral Trioxide Aggregate

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in in the same session.

TheraCal LC

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity (2 milimeter layer) and polymerized and restoration was finished in in the same session.

Theracal LC

Indirect pulp capping treatment with Theracal LC

Group Type EXPERIMENTAL

Calcium Hydroxide

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in the same session.

Mineral Trioxide Aggregate

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in in the same session.

TheraCal LC

Intervention Type DRUG

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity (2 milimeter layer) and polymerized and restoration was finished in in the same session.

Interventions

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Calcium Hydroxide

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in the same session.

Intervention Type DRUG

Mineral Trioxide Aggregate

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity and restoration was finished in in the same session.

Intervention Type DRUG

TheraCal LC

After cleaning the caries with partial removal (non-exposed pulp), cavity disinfected with sodium hypochlorite then indirect pulp capping agent was applied to cavity (2 milimeter layer) and polymerized and restoration was finished in in the same session.

Intervention Type DRUG

Other Intervention Names

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Dycal Pulp capping agent (ProRoot MTA) resin-based calcium silicate cement

Eligibility Criteria

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Inclusion Criteria

* teeth with clinical and radiographical indications of indirect pulp capping
* systemically healthy and cooperative children

Exclusion Criteria

* Pain (spontaneous and chronic)
* Fistula
* Acute pulpal inflammation
* Pain with percussion
* Pathologic mobility
* Abscess
* Progression of caries lesion to pulp
* Perforation of pulp
* Intermittent or irregular lamina dura
* Expanded range of periodontal ligament
* Periapical radiolucency
* Internal and external resorption
* systemically unhealthy and uncooperative children
Minimum Eligible Age

4 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Istanbul University

OTHER

Sponsor Role collaborator

Altinbas University

OTHER

Sponsor Role lead

Responsible Party

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Aliye Tugce Gurcan

Assist. Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aliye Tuğçe Gürcan, Assist.Prof.

Role: PRINCIPAL_INVESTIGATOR

Altinbas University

References

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Fuks AB. Vital pulp therapy with new materials for primary teeth: new directions and treatment perspectives. J Endod. 2008 Jul;34(7 Suppl):S18-24. doi: 10.1016/j.joen.2008.02.031.

Reference Type BACKGROUND
PMID: 18565366 (View on PubMed)

Marchi JJ, de Araujo FB, Froner AM, Straffon LH, Nor JE. Indirect pulp capping in the primary dentition: a 4 year follow-up study. J Clin Pediatr Dent. 2006 Winter;31(2):68-71. doi: 10.17796/jcpd.31.2.y4um5076341226m5.

Reference Type BACKGROUND
PMID: 17315796 (View on PubMed)

Gruythuysen RJ, van Strijp AJ, Wu MK. Long-term survival of indirect pulp treatment performed in primary and permanent teeth with clinically diagnosed deep carious lesions. J Endod. 2010 Sep;36(9):1490-3. doi: 10.1016/j.joen.2010.06.006.

Reference Type BACKGROUND
PMID: 20728715 (View on PubMed)

Gandolfi MG, Siboni F, Prati C. Chemical-physical properties of TheraCal, a novel light-curable MTA-like material for pulp capping. Int Endod J. 2012 Jun;45(6):571-9. doi: 10.1111/j.1365-2591.2012.02013.x. Epub 2012 Mar 31.

Reference Type BACKGROUND
PMID: 22469093 (View on PubMed)

Kotsanos N, Arizos S. Evaluation of a resin modified glass ionomer serving both as indirect pulp therapy and as restorative material for primary molars. Eur Arch Paediatr Dent. 2011 Jun;12(3):170-5. doi: 10.1007/BF03262801.

Reference Type BACKGROUND
PMID: 21640064 (View on PubMed)

Al-Zayer MA, Straffon LH, Feigal RJ, Welch KB. Indirect pulp treatment of primary posterior teeth: a retrospective study. Pediatr Dent. 2003 Jan-Feb;25(1):29-36.

Reference Type BACKGROUND
PMID: 12627699 (View on PubMed)

George V, Janardhanan SK, Varma B, Kumaran P, Xavier AM. Clinical and radiographic evaluation of indirect pulp treatment with MTA and calcium hydroxide in primary teeth (in-vivo study). J Indian Soc Pedod Prev Dent. 2015 Apr-Jun;33(2):104-10. doi: 10.4103/0970-4388.155118.

Reference Type BACKGROUND
PMID: 25872627 (View on PubMed)

Casagrande L, Bento LW, Dalpian DM, Garcia-Godoy F, de Araujo FB. Indirect pulp treatment in primary teeth: 4-year results. Am J Dent. 2010 Feb;23(1):34-8.

Reference Type BACKGROUND
PMID: 20437725 (View on PubMed)

Other Identifiers

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35793

Identifier Type: -

Identifier Source: org_study_id