Correlation Between VCL, AC and Spread of Intrathecal Hyperbaric Bupivacaine in the Term Parturient
NCT ID: NCT03606525
Last Updated: 2018-08-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
130 participants
OBSERVATIONAL
2018-08-21
2019-05-31
Brief Summary
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Detailed Description
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Effective surgical anaesthesia is the main objective of subarachnoid block. Therefore, adequate sensory blockade with minimal maternal and neonate side effects are warranted. The suitable level of sensory blockade post subarachnoid block for lower segment caesarean section is bilateral block up to T6 dermatome level to pinprick. This will block the somatic sensation and eliminate the visceral pain from peritoneal manipulation during caesarean section.
However, the spread of subarachnoid block may be variable. Various patient variables such as age, height, weight, body mass index, vertebral column length and abdominal girth influence the spread of subarachnoid block. Inadequate sensory blockade will cause parturient suffer from pain while excessive blockade will lead to unwanted sympathetic inhibition causing hypotension and bradycardia. Ability of an anaesthetist to determine optimal dose to achieve adequate level of sensory blockade yet with minimal unwanted side effects is crucial.
Incidence of maternal hypotension is related to the level of sensory blockade after subarachnoid block.And maternal hypotension is associated with maternal discomfort during caesarean section and poorer fetal outcomes. Therefore, this study is carried out to investigate whether vertebral column length and abdominal circumference affecting the spread of intrathecal hyperbaric bupivacaine in term parturient.
Previous studies showed conflicting results on the factors that influence the effect of spinal anaesthesia. One of the studies was carried out in China which might not reflect the investigator's local multiracial population characteristics. Previous studies also did not investigate the outcome of baby related to maternal hypotension which is known complication.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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subarachnoid block
Vertebral column length and abdominal girth will be measured before routine subarachnoid block is given to recruited patients
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) physical status I-II
* singleton pregnancy
* gestational age 37 weeks or more
* height 150-175cm and weight 50-100kg
Exclusion Criteria
* history of allergy to local anaesthetics
* contraindication to NSAIDS use
* failure of subarachnoid block
* any abnormality of spine
* history of spinal surgery
* refusal to participate in this research
18 Years
FEMALE
No
Sponsors
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University of Malaya
OTHER
Responsible Party
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Dr Soo Suet Ker
Medical officer, Department of Anaesthesiology, Principal investigator
Principal Investigators
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Suet Ker Soo
Role: PRINCIPAL_INVESTIGATOR
University of Malaya
Locations
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University Malaya Medical Centre
Kuala Lumpur, , Malaysia
Countries
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Central Contacts
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Facility Contacts
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References
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Zhou QH, Xiao WP, Shen YY. Abdominal girth, vertebral column length, and spread of spinal anesthesia in 30 minutes after plain bupivacaine 5 mg/mL. Anesth Analg. 2014 Jul;119(1):203-206. doi: 10.1213/ANE.0000000000000199.
Zhou QH, Zhu B, Wei CN, Yan M. Abdominal girth and vertebral column length can adjust spinal anesthesia for lower limb surgery, a prospective, observational study. BMC Anesthesiol. 2016 Mar 24;16:22. doi: 10.1186/s12871-016-0184-3.
Other Identifiers
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201843-6195
Identifier Type: -
Identifier Source: org_study_id
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