Efficacy of FLAG Regimen for the Treatment of Patients With AML

NCT ID: NCT03600558

Last Updated: 2020-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-21

Study Completion Date

2020-07-31

Brief Summary

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The long-term efficacy of chemotherapy in patients with acute myeloid leukemia (AML) has been significantly improved in recent years. The combination of anthracycline plus cytarabine (Ara-C) has been a standard induction regimen for patients with AML. However, the optimal consolidation therapy after induction chemotherapy has not reached a consensus. The FLAG regimen consisting of fludarabine and high-dose cytarabine combined with G-CSF which is one of the first-line consolidation treatment options for relapsed and refractory AML. This study conducted a retrospective analysis of the intensive treatment of AML with the FLAG regimen from January 2007 to May 2018 in our hospital to evaluate the efficacy of the FLAG regimen. To provide the basis for the choice and timing of treatment for patients with AML treated with the FLAG regimen.

Detailed Description

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Conditions

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Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient more than 18 year old
* De novo or secondary leukemia.
* Treated with FLAG regimen

Exclusion Criteria

* Acute promyelocytic leukemia (APL)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tianjin Medical University General Hospital

OTHER

Sponsor Role lead

Responsible Party

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ZhongHong Shao

head of department of Hematology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zonghong Shao, MD

Role: CONTACT

8602260817092

Facility Contacts

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Zonghong Shao, MD

Role: primary

Other Identifiers

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Handong

Identifier Type: -

Identifier Source: org_study_id

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