An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease

NCT ID: NCT03599622

Last Updated: 2024-07-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

239 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-16

Study Completion Date

2023-10-23

Brief Summary

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The purpose of this study is to assess the safety and effectiveness of BMS-986165 compared to placebo in participants with moderately to severely active Crohn's Disease.

Detailed Description

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Conditions

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Granulomatous Colitis Crohn's Disease Crohn's Enteritis Granulomatous Enteritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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BMS-986165 Dose 1

Group Type EXPERIMENTAL

BMS-986165

Intervention Type DRUG

Specified dose on specified days

BMS-986165 Dose 2

Group Type EXPERIMENTAL

BMS-986165

Intervention Type DRUG

Specified dose on specified days

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Specified dose on specified days

Interventions

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BMS-986165

Specified dose on specified days

Intervention Type DRUG

Placebo

Specified dose on specified days

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Documented diagnosis of Crohn's Disease (CD) for at least 3 months prior to screening, including ileal, colonic, or ileo-colonic disease distribution
* Must have had an inadequate response, loss of response, or intolerance to 1 or more of the standard treatments
* Must have active moderate to severe CD
* Men and women must agree to follow specific methods of contraception, if applicable

Exclusion Criteria

* Severe or fulminant colitis that is likely to require surgery or hospitalization
* Presence of a diagnosis of alternative forms of colitis (infectious, inflammatory including ulcerative colitis, malignant, toxic, indeterminate, etc.) other than Crohn's Disease
* Previous exposure to BMS-986165 in any study
* Any major illness/condition or evidence of an unstable clinical condition (eg, renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, immunologic, psychiatric, or local active infection/infectious illness) that, in the investigator's judgment, will substantially increase the risk to the participant
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0258

Los Angeles, California, United States

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Local Institution - 0247

Aurora, Colorado, United States

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Local Institution - 0001

Hamden, Connecticut, United States

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Local Institution - 0255

Clearwater, Florida, United States

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Local Institution - 0259

Jacksonville, Florida, United States

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Local Institution - 0261

Jacksonville, Florida, United States

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Local Institution - 0276

Largo, Florida, United States

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Local Institution - 0232

Miami, Florida, United States

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Local Institution - 0162

New Port Richey, Florida, United States

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Local Institution - 0201

Orlando, Florida, United States

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Local Institution - 0249

Orlando, Florida, United States

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Local Institution - 0166

Tampa, Florida, United States

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Local Institution - 0248

Zephyrhills, Florida, United States

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Local Institution - 0277

Suwanee, Georgia, United States

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Local Institution - 0358

Suwanee, Georgia, United States

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Local Institution - 0319

Chicago, Illinois, United States

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Local Institution - 0346

Glenview, Illinois, United States

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Local Institution - 0301

Indianapolis, Indiana, United States

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Local Institution - 0253

Iowa City, Iowa, United States

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Local Institution - 0282

Shreveport, Louisiana, United States

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Local Institution - 0003

Chesterfield, Michigan, United States

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Local Institution - 0218

Chesterfield, Michigan, United States

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Local Institution - 0047

Wyoming, Michigan, United States

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Local Institution - 0223

Ypsilanti, Michigan, United States

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Local Institution - 0231

Jackson, Mississippi, United States

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Local Institution - 0156

Ocean Springs, Mississippi, United States

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Local Institution - 0359

St Louis, Missouri, United States

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Local Institution - 0011

Las Vegas, Nevada, United States

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Local Institution - 0043

Lake Success, New York, United States

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Local Institution - 0308

New York, New York, United States

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Local Institution - 0226

Monroe, North Carolina, United States

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Local Institution - 0349

Oklahoma City, Oklahoma, United States

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Local Institution - 0238

Hershey, Pennsylvania, United States

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Local Institution - 0125

Pittsburgh, Pennsylvania, United States

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Local Institution - 0122

Sayre, Pennsylvania, United States

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Local Institution - 0357

Wyomissing, Pennsylvania, United States

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Local Institution - 0105

Charleston, South Carolina, United States

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Local Institution - 0072

Nashville, Tennessee, United States

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Local Institution - 0264

Arlington, Texas, United States

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Local Institution - 0246

Garland, Texas, United States

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Local Institution - 0252

San Antonio, Texas, United States

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Local Institution - 0307

San Antonio, Texas, United States

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Local Institution - 0073

Southlake, Texas, United States

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Local Institution - 0240

Spring, Texas, United States

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Local Institution - 0302

Tyler, Texas, United States

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Lynchburg, Virginia, United States

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Local Institution - 0224

Richmond, Virginia, United States

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Local Institution - 0327

Seattle, Washington, United States

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Local Institution - 0266

Seattle, Washington, United States

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Local Institution - 0191

Seattle, Washington, United States

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Local Institution - 0331

Vancouver, Washington, United States

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Local Institution - 0356

Milwaukee, Wisconsin, United States

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Local Institution - 0268

South Brisbane, Queensland, Australia

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Local Institution - 0254

Woolloongabba, Queensland, Australia

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Local Institution - 0265

Adelaide, South Australia, Australia

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Local Institution - 0289

Woodville, South Australia, Australia

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Local Institution - 0042

Ballarat, Victoria, Australia

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Clayton, Victoria, Australia

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Local Institution - 0040

Melbourne, Victoria, Australia

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Local Institution - 0351

Melbourne, Victoria, Australia

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Local Institution - 0275

Murdoch, Western Australia, Australia

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Local Institution - 0316

Antwerp, , Belgium

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Local Institution - 0305

Edegem, , Belgium

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Local Institution - 0322

Ghent, , Belgium

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Local Institution - 0314

Yvoir, , Belgium

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Local Institution - 0256

Salvador, Estado de Bahia, Brazil

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Local Institution - 0262

Salvador, Estado de Bahia, Brazil

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Local Institution - 0069

Juiz de Fora, Minas Gerais, Brazil

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Local Institution - 0086

Porto Alegre, Rio Grande do Sul, Brazil

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Local Institution - 0058

Botucato, São Paulo, Brazil

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Santo André, São Paulo, Brazil

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São Bernardo do Campo, São Paulo, Brazil

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Local Institution - 0085

São José do Rio Preto, São Paulo, Brazil

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Local Institution - 0017

Rio de Janeiro, , Brazil

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Local Institution - 0048

Calgary, Alberta, Canada

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Local Institution - 0324

Edmonton, Alberta, Canada

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Local Institution - 0300

Edmonton, Alberta, Canada

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Local Institution - 0159

Vancouver, British Columbia, Canada

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Etobicoke, Ontario, Canada

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Local Institution - 0312

London, Ontario, Canada

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Local Institution - 0236

Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Xiamen, Fujian, China

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Guangzhou, Guangdong, China

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Guangzhou, Guangdong, China

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Changsha, Hunan, China

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Nanjing, Jiangsu, China

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Nanjing, Jiangsu, China

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Changchun, Jilin, China

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Local Institution - 0299

Shenyang, Liaoning, China

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Shanghai, Shanghai Municipality, China

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Local Institution - 0234

Shanghai, Shanghai Municipality, China

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Local Institution - 0337

Brno, , Czechia

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Brno, , Czechia

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Local Institution - 0057

Hradec Králové, , Czechia

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Ostrava, , Czechia

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Ostrava, , Czechia

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Pardubice, , Czechia

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Prague, , Czechia

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Aalborg, , Denmark

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Copenhagen NV, , Denmark

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Odense, , Denmark

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Clichy, , France

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Colombes, , France

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Montpellier, , France

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Saint-Etienne, , France

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Toulouse, , France

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Toulouse, , France

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Berlin, , Germany

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Berlin, , Germany

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Brandenburg, , Germany

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Frankfurt, , Germany

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Halle, , Germany

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Halle, , Germany

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Hanover, , Germany

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Jena, , Germany

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Kiel, , Germany

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Mannheim, , Germany

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Münster, , Germany

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Regensburg, , Germany

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Tübingen, , Germany

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Ulm, , Germany

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Békéscsaba, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Budapest, , Hungary

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Debrecen, , Hungary

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Gyöngyös, , Hungary

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Mohács, , Hungary

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Szeged, , Hungary

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Vác, , Hungary

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Tallaght, Dublin, Ireland

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Local Institution - 0335

Ballinasloe, Galway, Ireland

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Local Institution - 0336

Drogheda, Louth, Ireland

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Dublin, , Ireland

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Galway, , Ireland

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Local Institution - 0197

Beersheba, , Israel

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Local Institution - 0186

Nahariya, , Israel

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Petah Tikva, , Israel

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Rehovot, , Israel

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Local Institution - 0290

Bologna, , Italy

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Local Institution - 0298

Castellana Grotte, , Italy

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Catanzaro, , Italy

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Messina, , Italy

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Milan, , Italy

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Local Institution - 0115

Milan, , Italy

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Local Institution - 0311

Milan, , Italy

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Local Institution - 0297

Monserrato, , Italy

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Negrar, , Italy

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Padua, , Italy

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Pavia, , Italy

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Roma, , Italy

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Rozzano, , Italy

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Torino, , Italy

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Toyoake, Aichi-ken, Japan

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Local Institution - 0199

Hirosaki, Aomori, Japan

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Sakura-shi, Chiba, Japan

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Local Institution - 0328

Tōon, Ehime, Japan

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Fukui-shi, Fukui, Japan

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Chikushino-shi, Fukuoka, Japan

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Kurume-shi, Fukuoka, Japan

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Sapporo, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Nishinomiya, Hyōgo, Japan

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Sagamihara-shi, Kanagawa, Japan

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Sendai, Miyagi, Japan

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Local Institution - 0194

Omura-shi, Nagasaki, Japan

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Local Institution - 0318

Urasoe-Shi, Okinawa, Japan

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Suita-shi, Osaka, Japan

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Ōtsu, Shiga, Japan

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Local Institution - 0189

Hamamatsu, Shizuoka, Japan

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Local Institution - 0213

Bunkyo-ku, Tokyo, Japan

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Local Institution - 0195

Minato-ku, Tokyo, Japan

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Local Institution - 0188

Hiroshima, , Japan

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Local Institution - 0206

Kyoto, , Japan

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Local Institution - 0214

Miyazaki, , Japan

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Local Institution - 0196

Saga, , Japan

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Local Institution - 0203

Sapporo, , Japan

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Local Institution - 0106

Guadalajara, Jalisco, Mexico

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Local Institution - 0007

Mexico City, Mexico City, Mexico

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Local Institution - 0009

Cuernavaca, Morelos, Mexico

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Local Institution - 0109

Monterrey, Nuevo León, Mexico

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Local Institution - 0029

Querétaro, , Mexico

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Local Institution - 0303

Amsterdam, , Netherlands

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Bydgoszcz, , Poland

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Bydgoszcz, , Poland

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Krakow, , Poland

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Local Institution - 0284

Lodz, , Poland

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Local Institution - 0098

Lodz, , Poland

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Local Institution - 0291

Lublin, , Poland

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Local Institution - 0278

Nowy Targ, , Poland

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Local Institution - 0176

Olsztyn, , Poland

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Sopot, , Poland

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Local Institution - 0063

Tychy, , Poland

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Local Institution - 0271

Warsaw, , Poland

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Local Institution - 0288

Warsaw, , Poland

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Local Institution - 0026

Warsaw, , Poland

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Local Institution - 0279

Warsaw, , Poland

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Local Institution - 0160

Wroclaw, , Poland

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Local Institution - 0034

Wroclaw, , Poland

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Local Institution - 0174

Guimarães, , Portugal

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Local Institution - 0216

Santa Maria da Feira, , Portugal

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Local Institution - 0067

Bucharest, , Romania

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Local Institution - 0044

Bucharest, , Romania

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Local Institution - 0163

Bucharest, , Romania

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Local Institution - 0074

Bucharest, , Romania

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Local Institution - 0005

Timișoara, , Romania

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Local Institution - 0060

Timișoara, , Romania

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Bioterm

Barnaul, , Russia

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Hospital Irkutsk Scientific Center

Irkutsk, , Russia

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Republican Clinical Hospital Ministry of Health Republic of Tatarstan

Kazan', , Russia

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City Clinical Hospital Number 24

Moscow, , Russia

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Medical Center SibNovoMed

Novosibirsk, , Russia

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Novosibirsk Gastrocenter

Novosibirsk, , Russia

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Novosibirsk State Regional Clinical Hospital

Novosibirsk, , Russia

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Medical Center Healthy Family

Novosibirsk, , Russia

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Clinic Ultrasound 4D

Pyatigorsk, , Russia

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Saint Petersburg State Budgetary Institution of Health City Hospital of the Holy Martyr Elizabeth

Saint Petersburg, , Russia

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Saratov Regional Clinical Hospital

Saratov, , Russia

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Tomsk Regional Clinical Hospital

Tomsk, , Russia

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Multidisciplinary Consultative and Diagnostic Center

Tyumen, , Russia

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Novgorod Regional Clinical Hospital

Veliky Novgorod, , Russia

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Local Institution - 0046

Seongnam-si, Gyeonggi-do, South Korea

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Local Institution - 0158

Ansan-si, , South Korea

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Local Institution - 0149

Busan, , South Korea

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Local Institution - 0064

Daegu, , South Korea

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Local Institution - 0061

Daegu, , South Korea

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Local Institution - 0150

Incheon, , South Korea

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Local Institution - 0015

Seoul, , South Korea

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Local Institution - 0016

Seoul, , South Korea

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Local Institution - 0012

Wŏnju, , South Korea

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Yangsan, , South Korea

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Local Institution - 0329

Alicante, , Spain

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Local Institution - 0274

Barcelona, , Spain

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Local Institution - 0154

Fuenlabrada, , Spain

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Local Institution - 0080

Girona, , Spain

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Local Institution - 0021

Las Palmas de Gran Canaria, , Spain

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LHospitalet de Llobregat, , Spain

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Local Institution - 0325

Sabadell, , Spain

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Local Institution - 0113

Santander, , Spain

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Local Institution - 0309

Santiago de Compostelle, , Spain

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Local Institution - 0313

Seville, , Spain

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Local Institution - 0107

Seville, , Spain

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Local Institution - 0004

Valencia, , Spain

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Local Institution - 0180

Bern, , Switzerland

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Local Institution - 0173

Kaohsiung City, , Taiwan

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Local Institution - 0148

Taichung, , Taiwan

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Local Institution - 0267

Taipei, , Taiwan

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Local Institution - 0152

Taoyuan District, , Taiwan

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Local Institution - 0341

Birmingham, , United Kingdom

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Local Institution - 0144

Blackpool, , United Kingdom

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Local Institution - 0235

Cambridge, , United Kingdom

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Local Institution - 0354

Cannock, , United Kingdom

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Local Institution - 0165

Cheshire, , United Kingdom

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Local Institution - 0157

Glasgow, , United Kingdom

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Local Institution - 0353

Manchester, , United Kingdom

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Local Institution - 0208

Swansea, , United Kingdom

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Countries

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United States Australia Belgium Brazil Canada China Czechia Denmark France Germany Hungary Ireland Israel Italy Japan Mexico Netherlands Poland Portugal Romania Russia South Korea Spain Switzerland Taiwan United Kingdom

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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2017-001976-48

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

IM011-023

Identifier Type: -

Identifier Source: org_study_id

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