Outcomes of Liver Transplantation in Low Weight Children After Reducing the Lateral Segment of a Living Donor, Adapting the Shape and Size of the Graft to the Needs of the Recipient

NCT ID: NCT03594864

Last Updated: 2018-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

58 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-21

Study Completion Date

2018-06-03

Brief Summary

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The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size. Different techniques of hepatic reduction have been described that allow to use larger organs in the pediatric population. However, in these techniques the maximum reduction achieved by segments 2 and 3 is excessive for low-weight children. Since 1997 the liver transplantation group at Hospital Italiano de Buenos Aires has developed and practiced a technique called hepatic hyper-reduction, which consists in reducing the lateral segment of a living donor, adapting the shape and size of the graft to the needs of the recipient. The investigators have performed approximately 50 pediatric liver transplants with live donors in low weight children in whom the hyper-reduction technique has been applied. The aim of the present study is to describe postoperative morbidity and mortality and analyze overall and graft survival.

Detailed Description

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Conditions

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Liver Transplantation Low-weight Children Hyper-reduced Liver Grafts

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Hyper-reduced liver recipients.

Low-weight children who underwent live donor liver transplantation with ultrasound-guided in situ left lateral segment graft hyper-reduction.

Liver transplantation with hyper-reduced grafts

Intervention Type PROCEDURE

Live donor liver transplantation using non-anatomical in-situ ultrasound-guided reduction of left lateral segments with preparation of a graft that is larger than a monosegment, but smaller than Segments 2 and 3.

Interventions

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Liver transplantation with hyper-reduced grafts

Live donor liver transplantation using non-anatomical in-situ ultrasound-guided reduction of left lateral segments with preparation of a graft that is larger than a monosegment, but smaller than Segments 2 and 3.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* \< or = 17 years old.
* Having undergone live donor liver transplantation.
* Having received hyper-reduced liver grafts
* At the Liver Transplantation Unit of the Hospital Italiano de Buenos Aires
* Between June 1997 and April 2018

Exclusion Criteria

* \> 17 years old.
* Cadaveric liver transplant
* Whole liver grafts.
Minimum Eligible Age

5 Months

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Italiano de Buenos Aires

OTHER

Sponsor Role lead

Responsible Party

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MICAELA RAICES

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Micaela Raices, Physician

Role: PRINCIPAL_INVESTIGATOR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Matias E Czerwonko, Physician

Role: STUDY_CHAIR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Victoria Ardiles, Physician

Role: STUDY_CHAIR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Gustavo Boldrini, Physician

Role: STUDY_CHAIR

Department of Pediatrics, Division of Pediatric Gastroenterology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Daniel D'Agostino, Physician

Role: STUDY_CHAIR

Department of Pediatrics, Division of Pediatric Gastroenterology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

José Marcó del Pont, Physician

Role: STUDY_CHAIR

Department of Pediatrics, Division of Pediatric Infectious Diseases, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Juan Pekolj, Doctor

Role: STUDY_CHAIR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Eduardo de Santibañes, Doctor

Role: STUDY_CHAIR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Martin de Santibañes, Physician

Role: STUDY_DIRECTOR

Department of General Surgery, Division of HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Locations

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Hospital Italiano de Buenos Aires

Capital Federal, , Argentina

Site Status

Countries

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Argentina

Other Identifiers

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321654

Identifier Type: -

Identifier Source: org_study_id

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