Experiment 2: Understanding Liver Fat Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2021-01-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

There is a largely unsubstantiated thought in the literature that dietary unsaturated enter oxidation pathways preferentially compared to saturated fatty acids. This study is undertaking a direct comparison of the oxidation of dietary saturated and unsaturated fatty acids.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Understanding the Role of Dietary Fatty Acids on Liver Fat Metabolism in Humans

NCT01936779

NAFLD

COMPLETED NA

Effects of Dietary Nutrients on Liver and Adipose Tissue Metabolism

NCT03090347

NAFLD Nutrient; Excess

UNKNOWN NA

Short-term Fat Overfeeding on the Effects of Liver Metabolism

NCT05962190

Liver Fat Cardiac Function Lipid Disorder +1 more

RECRUITING NA

Dietary Correlates of the Maximal Capacity for Fat Oxidation

NCT02070055

Maximal Rate of Fat Oxidation

COMPLETED

Kinetics of Metabolic Cofactors in NAFLD

NCT03838822

Healthy

COMPLETED EARLY_PHASE1

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Provided subjects meet the inclusion criteria, then at least one week after the screening visit volunteers will then undertake the first two 'study days'. There will be two study days on separate occasions that will be up to 3 weeks apart. Each study day will be approximately 7 hours in duration. On each study day participants will be given a standardised 'test' meal that contains specially labelled fat molecules (stable-isotope tracer) and then repeated breath and blood samples will be taken over the course of the next 6 hours. The test meal consumed on each 'study day' will be identical in composition with only the specially labelled fat molecules being different (either unsaturated or saturated fat) and these will be given in a random order.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Fatty Acid Oxidation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomised cross-over

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Unsaturated

A test meal containing a unsaturated fatty acid labelled with 13C to measure hepatic fatty acid partitioning.

Group Type ACTIVE_COMPARATOR

Dietary fatty acid partitioning

Intervention Type OTHER

There is no intervention as such, just a physiological assessment of the partitioning and oxidation of two different types of dietary fatty acids

Saturated

A test meal containing a saturated fatty acid labelled with 13C to measure hepatic fatty acid partitioning

Group Type ACTIVE_COMPARATOR

Dietary fatty acid partitioning

Intervention Type OTHER

There is no intervention as such, just a physiological assessment of the partitioning and oxidation of two different types of dietary fatty acids

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dietary fatty acid partitioning

There is no intervention as such, just a physiological assessment of the partitioning and oxidation of two different types of dietary fatty acids

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Participant is willing and able to give informed consent for participation in the study.

Male or Female, aged \>18 and \<65 years BMI \>19 \<35kg/m2 No medical condition or relevant drug therapy known to affect liver metabolism

Exclusion Criteria

* • Age \<18 or \>65 years

* Body mass index \<19 or \>35kg/m2
* A blood haemoglobin \<120mg/dL
* Any metabolic condition or relevant drug therapy
* Smoking
* History of alcoholism or a greater than recommended alcohol intake
* Pregnant or nursing mothers
* Women prescribed hormone replacement therapy (HRT) or who have used this within the last 12 months
* History of severe claustrophobia
* Presence of metallic implants, pacemaker
* Haemorrhagic disorders
* Anticoagulant treatment

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes