Sardine-enriched Diet for Prevention Type 2 Diabetes

NCT ID: NCT03557541

Last Updated: 2018-07-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

182 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2017-07-31

Brief Summary

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The hypothesis formulated is that 200 g of sardine on a weekly basis will have a favourable impact avoiding the natural development of the pathology due to changes in the biochemical profile, the anthropometrics, inflammatory markers, changes in gut microbiota populations, also in transcriptomics and metabolomics.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2 PreDiabetes Diet Habit Diabetes Nutritional and Metabolic Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Sardine group

Group Type EXPERIMENTAL

Sardine

Intervention Type DIETARY_SUPPLEMENT

They received 200gr of canned sardine in olive oil per week (+a common T2D-preventive diet)

Control group

Group Type ACTIVE_COMPARATOR

Control

Intervention Type DIETARY_SUPPLEMENT

They received a common T2D-preventive diet

Interventions

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Sardine

They received 200gr of canned sardine in olive oil per week (+a common T2D-preventive diet)

Intervention Type DIETARY_SUPPLEMENT

Control

They received a common T2D-preventive diet

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* glycaemia between 100-125 md / dL or ≥5.7% HbA1c

Exclusion Criteria

* treatment with oral antidiabetic drugs
* any nutritional education to prevent T2D
* Suspect or known hypersensitivity to sardine or related fish
* Chronic treatment with oral steroids and / or AINES
* Treatment with oral antidiabetic agents and / or insulin
* Treatment with immunosuppressive drugs
* Diagnosis of active neoplasm
* Diagnosis of HIV or AIDS
* Abnormal liver profile (\> 6 times normal values)
* Diagnosis of Acute Psychiatric Sdr
* Presence of serious acute concomitant disease, which it requires more than 7 days of recovery.
* Major cardiovascular event (stroke, myocardial infarction) in the month prior to randomization.
* Any other condition that the investigator considers to be inoperative so that the subject conducts the study.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Institut d'Investigacions Biomèdiques August Pi i Sunyer

OTHER

Sponsor Role lead

Responsible Party

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Diana Alicia Diaz Rizzolo

RD, Msc, PhD candidate

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Diana A Diaz Rizzolo

Barcelona, , Spain

Site Status

Countries

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Spain

References

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Diaz-Rizzolo DA, Serra A, Colungo C, Sala-Vila A, Siso-Almirall A, Gomis R. Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial. Clin Nutr. 2021 May;40(5):2587-2598. doi: 10.1016/j.clnu.2021.03.014. Epub 2021 Mar 18.

Reference Type DERIVED
PMID: 33932804 (View on PubMed)

Provided Documents

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Document Type: Informed Consent Form

View Document

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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2013/8863

Identifier Type: -

Identifier Source: org_study_id

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