Impact of Genotyping P450 2C19 on Hospitalization Period
NCT ID: NCT03554239
Last Updated: 2018-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2016-12-31
2017-12-31
Brief Summary
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Detailed Description
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Thus, a new strategy will be proposed as part of this project and will be compared to the reference strategy:
The New strategy: genotyping of CYP2C19 in any patient receiving treatment with Voriconazole in order to better adapt the treatment regimen as quickly as possible (increase of the dosage of Voriconazole in high-speed metabolisers or use of another antifungal, decreased dosage in poor metabolisers).
The Reference strategy: pharmacological therapeutic monitoring of Voriconazole allowing an adaptation of the Voriconazole dosage based on the residual concentration measured once steady state has been reached (5 elimination half-lives).
Multicenter, randomized study comparing two strategies of Voriconazole adaptation according to whether or not genotyping of CYP2C19 is performed as soon as Voriconazole is started.
Thus, the new strategy tested in this project and compared to the reference strategy (adaptation of Voriconazole dosage depending on the residual concentration), will be a genotyping of CYP2C19 in any patient receiving a treatment based on Voriconazole in order to better adapt the treatment regimen as quickly as possible (increase in the dosage of Voriconazole or use of another antifungal agent in ultra-rapid metabolisers, decrease in dosage in poor metabolisers).
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Voriconazole treatment
Patients who start voriconazole treatment and receive benefits of genotyping
genotyping
Blood sample
Interventions
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genotyping
Blood sample
Eligibility Criteria
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Inclusion Criteria
* Man or woman
* With social security number
Exclusion Criteria
* All patient under protection of adults
ALL
No
Sponsors
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University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Peggy Gandia, PharmD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse
Other Identifiers
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RC31/15/7853
Identifier Type: -
Identifier Source: org_study_id