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Taste Changes With Bariatric Surgery

NCT ID: NCT03548038

Last Updated: 2020-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-24

Study Completion Date

2020-05-04

Brief Summary

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It is commonly believed that a link exists between BMI and taste perception. One group of researchers observed that women who are obese experience reduced taste sensitivity when compared to normal-weight controls. Others have compared taste sensitivity between lean and obese subjects and found no significant differences. The inconsistencies in these studies demonstrate how much variation in taste sensitivity is possible when different factors are applied in research. Throughout several studies, one element remains constant - bariatric surgery causes appetite aversions. These changes in appetite and food preference likely have a large influence on the overall magnitude of post-surgical weight loss. Although many studies have investigated the changes in taste preference after bariatric surgery, few, if any, have focused on changes in sweet taste perception.

Detailed Description

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The overall goal of the present project is to determine how future bariatric surgery will affect the taste for sweet liquids. Taste perception will be assessed before surgery (pre-operative, pre-op) and after bariatric surgery, at approximately 1 month. Taste studies will be conducted with solutions prepared freshly before each test using sucrose dissolved in distilled water. Six concentrations of sucrose (table sugar) will be tasted in random order, with the most concentrated solution being roughly the sweetness of soda. The subject is blinded to the concentrations. It is hypothesized that there will be no significant difference in taste perception when pre-op and post-op values are compared. However, the investigators hypothesize that taste preference will identify solutions with lower concentrations post-op.

Conditions

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Taste, Altered

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Bariatric surgery patients

All subjects will be patients scheduled for bariatric surgery. There is only one arm in this study.

taste test

Intervention Type OTHER

All subjects will complete a procedure to determine their taste sensitivity to sweet tastants.

Interventions

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taste test

All subjects will complete a procedure to determine their taste sensitivity to sweet tastants.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women who plan to undergo bariatric surgery.
* Age: 21-70y.
* Non-smokers (at least 3 months post smoking cessation).
* Non-diabetic or prediabetic

Exclusion Criteria

* Subject on a medication known to affect taste perception: Antibiotics, thyroid medications, psychotropic, neurological, and cardiac medications.
* Inability to understand the test instructions.
* Subject has already undergone bariatric surgery
Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Missouri-Columbia

OTHER

Sponsor Role lead

Responsible Party

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Elizabeth Parks

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elizabeth J Parks, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Missouri-Columbia

Locations

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Elizabeth Parks

Columbia, Missouri, United States

Site Status

University of Missouri

Columbia, Missouri, United States

Site Status

Countries

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United States

References

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Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, le Roux CW. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiol Behav. 2011 Oct 24;104(5):709-21. doi: 10.1016/j.physbeh.2011.07.025. Epub 2011 Jul 30.

Reference Type BACKGROUND
PMID: 21827777 (View on PubMed)

Scruggs DM, Buffington C, Cowan GS Jr. Taste Acuity of the Morbidly Obese before and after Gastric Bypass Surgery. Obes Surg. 1994 Feb;4(1):24-28. doi: 10.1381/096089294765558854.

Reference Type BACKGROUND
PMID: 10742759 (View on PubMed)

Pepino MY, Finkbeiner S, Beauchamp GK, Mennella JA. Obese women have lower monosodium glutamate taste sensitivity and prefer higher concentrations than do normal-weight women. Obesity (Silver Spring). 2010 May;18(5):959-65. doi: 10.1038/oby.2009.493. Epub 2010 Jan 14.

Reference Type BACKGROUND
PMID: 20075854 (View on PubMed)

Other Identifiers

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2011543

Identifier Type: -

Identifier Source: org_study_id