Clinical Evaluation of a Wearable Sleep Diagnosis Technology

NCT ID: NCT03544086

Last Updated: 2020-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-10

Study Completion Date

2020-09-15

Brief Summary

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The primary endpoint is to evaluate the sensitivities and specificities for diagnosis of sleep apnoea of a wearable sleep diagnosis technology vs. existing gold standard.

Detailed Description

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The clinical investigation will be performed at the Royal Free London Hospital. Physiological signals will be pseudo-anonymized and only viewed by the research team.

The Study will involve patients who will have been referred for diagnosis of sleep apnoea, will aim to determine AcuPebble's positive and negative predictive ratios, sensitivities as specificities. Likelihood ratios for diagnosis of sleep apnoea. Clinical experts will determine patients' diagnostic information using the current diagnostic standards. AcuPebble will also generate diagnostic results independently and automatically. Both set of results will be subsequently compared and the relevant performance metrics listed above will be determined.

Consecutive patients referred for sleep study will be recruited to the study. Patients that are willing to participate will be consented on the day of their sleep study and sent home with both - the Trusts usual multichannel polygraphy and the Acupebble.

Conditions

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Obstructive Sleep Apnea

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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test group

First group is the first 10 patients

No interventions assigned to this group

study group

following 150 patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who have been referred to a sleep clinic due to suspicion of sleep apnoea.

Exclusion Criteria

* Age under 18 or over 70 years.
* Subjects who are not fluent in English, or who have special communication needs.
* Known allergy to the adhesive dressing.
* Subjects with physical or mental impairments who would not be able to use the new technology on their own.
* Subjects with very loose/saggy skin in the neck area which would unavoidably result on - AcuPebble swinging if moving the neck.
* Subjects with pacemakers.
* exclude patients who have any type of implanted electronic devices (these include patients in ICDs and left ventricular assist devices and loop recorders).
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Royal Free Hospital NHS Foundation Trust

OTHER

Sponsor Role collaborator

Acurable Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr Swapna Mandal, BSc MBBS MRCP SCE, PhD

Role: PRINCIPAL_INVESTIGATOR

Royal Free NHS Hospital

Locations

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Royal Free Hospital

London, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Devani N, Pramono RXA, Imtiaz SA, Bowyer S, Rodriguez-Villegas E, Mandal S. Accuracy and usability of AcuPebble SA100 for automated diagnosis of obstructive sleep apnoea in the home environment setting: an evaluation study. BMJ Open. 2021 Dec 21;11(12):e046803. doi: 10.1136/bmjopen-2020-046803.

Reference Type DERIVED
PMID: 34933855 (View on PubMed)

Other Identifiers

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225818

Identifier Type: OTHER

Identifier Source: secondary_id

225818

Identifier Type: -

Identifier Source: org_study_id