Relationship of Different Electrocardiographic Parameters and Ambulatory Blood Pressure Parameters to Detect Left Ventricular Hypertrophy

NCT ID: NCT03542526

Last Updated: 2018-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

73 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2022-12-31

Brief Summary

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To review the accuracy of electrocardiography in screening for left ventricular hypertrophy in patients with hypertension.

Detailed Description

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Arterial hypertension is a major cause of coronary heart disease, stroke, and heart failure. Several studies have shown that left ventricular hypertrophy is an important risk factor in patients with hypertension, leading to a fivefold to 10-fold increase in cardiovascular risk,1 2 3 4 5 which is similar to the increase seen in patients with a history of myocardial infarction.6 The presence of left ventricular hypertrophy, in addition to hypertension, thus has important implications for assessing risk and managing patients, including decisions on interventions other than antihypertensive treatment, such as lipid lowering treatment and lifestyle modifications.7 8 Accurate and early diagnosis of left ventricular hypertrophy is therefore an important component of the care of patients with hypertension.

Decisions about treatment should be based on assessments of hypertensive target organ damage and overall cardiovascular risk. The appropriate diagnostic work-up of suspected left ventricular hypertrophy in patients with hypertension is less clear, however. There is many electrocardiographic indexes for the diagnosis of left ventricular hypertrophy, based on the standard 12 lead electrocardiogram, have been described. Many of the proposed indexes have remained anecdotal, but others are commonly used, including the Sokolow-Lyon index,9 the Cornell voltage index,10 the Cornell product index,11 the Gubner index,12 and the Romhilt-Estes scores.13 However, debate about their comparative diagnostic value continues.14 15 We did a systematic review to clarify the accuracy of different electrocardiographic indexes, with emphasis on their ability to rule out left ventricular hypertrophy in patients with arterial hypertension.

Conditions

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Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Interventions

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electrogradiogram

12 lead ecg ambulatory blood prussre

Intervention Type DEVICE

ambulatory blood prussre

ambulatory blood pressure to measure blood pressure

Intervention Type DEVICE

Other Intervention Names

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blood measuring device

Eligibility Criteria

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Inclusion Criteria

Patients ranging from 20t o 80 years attending the hypertension outpatient clinic for ambulatory blood pressure measurement will be consecutively enrolled

Exclusion Criteria

1. Patients with ischemic heart disease.
2. Patients with advanced respiratory, renal, or hepatic disease
3. Patients with uninterpretable ECG or ABPM recordings
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Michael Sadeq

cardiology resident, principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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AssiutU

Asyut, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Yehia t Keshk, professor

Role: CONTACT

Phone: 20882335120

Email: [email protected]

Tarek a nagib, lecturer

Role: CONTACT

Phone: 201099975128

Email: [email protected]

Facility Contacts

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Yehia T Keshk, professor

Role: primary

Tarek a nagib, lecturer

Role: backup

References

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Jain A, Tandri H, Dalal D, Chahal H, Soliman EZ, Prineas RJ, Folsom AR, Lima JA, Bluemke DA. Diagnostic and prognostic utility of electrocardiography for left ventricular hypertrophy defined by magnetic resonance imaging in relationship to ethnicity: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2010 Apr;159(4):652-8. doi: 10.1016/j.ahj.2009.12.035.

Reference Type BACKGROUND
PMID: 20362725 (View on PubMed)

Pewsner D, Juni P, Egger M, Battaglia M, Sundstrom J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ. 2007 Oct 6;335(7622):711. doi: 10.1136/bmj.39276.636354.AE. Epub 2007 Aug 28.

Reference Type BACKGROUND
PMID: 17726091 (View on PubMed)

Related Links

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856691/

Diagnostic and Prognostic Utility of ECG for Left Ventricular Hypertrophy Defined by MRI in Relationship to Ethnicity: The Multi-Ethnic Study of Atherosclerosis (MESA)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001078/

Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review

Other Identifiers

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LVHTN

Identifier Type: -

Identifier Source: org_study_id