Follow-up in Gynecological Cancer Survivors

NCT ID: NCT03515993

Last Updated: 2024-01-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-21

Study Completion Date

2024-04-30

Brief Summary

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A cross-sectional prospective study of follow-up in gynecologic cancer patients after primary treatment

Detailed Description

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The objective of this study is to identify physical and psychosocial problems and needs after treatment for gynecological cancer.

1100 patients stratified by cancer sites and treatment - a minimum of 120 patients within each stratum - will be recruited.

Institutional data on follow-up policy, demographic and clinical data (related to treatment history and tumor characteristics) will be collected. Patients will complete a set of 76 Quality of Life questions, at one single time point.

Descriptive analyses will be conducted to characterize the collected data. Multivariate model building will be used to identify patterns of physical, psychological and social problems based on factors specific to the patient and to the disease. Logistic multinomial or continuous regression analysis will be used to investigate which socio-demographic, clinical variables, or institutional are associated significantly with compromised quality of life and sexual health outcomes. Exploratory factor analysis will be used to explore the factor structure of the various PROMs to identify issue clustering.

Conditions

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Gynecologic Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Histological proven gynecological cancer (cervical, endometrial, ovarian (including fallopian tube and peritoneal primary), vulva).
* FIGO stage I-IV before completion of primary therapy.
* Disease-free without any evidence of relapse: no symptoms or signs potentially indicating recurrent disease (assessed according to standard clinical parameters using physical and gynecological examination, blood tests, CA 125 (ovarian cancer), or radiological imaging techniques).
* At least 6 months but no more than 5 years since completion of primary treatment.
* Performance status 0, 1 or 2 (WHO scale).
* Age ≥ 18 years.
* Ability to understand and fill out questionnaires.
* Written informed consent according to ICH/GCP, and national/local regulations.

Exclusion Criteria

* Other cancer diagnosis in the past 5 years.
* Patients participating in interventional clinical studies with Quality of Life as primary endpoint.
* Any psychological (including pre-existing psychiatric disorders), familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Medical University of Graz

Graz, , Austria

Site Status

ZNA Middelheim

Antwerp, , Belgium

Site Status

Universitair Ziekenhuis Gent

Ghent, , Belgium

Site Status

Centre Hospitalier Chretien (CHC) - CHC MontLegia

Liège, , Belgium

Site Status

ZNA Jan Palfijn

Merksem, , Belgium

Site Status

Universitaetsklinikum Schleswig-Holstein - Campus Kiel

Kiel, , Germany

Site Status

HELIOS Kliniken - Helios Klinikum Wuppertal - Klin. Univ. Witten / Herdecke

Wuppertal, , Germany

Site Status

Ospedale San Gerardo

Monza, , Italy

Site Status

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Napoli, , Italy

Site Status

Azienda Ospedaliera Ordine Mauriziano di Torino

Torino, , Italy

Site Status

King Hussein Cancer Center

Amman, , Jordan

Site Status

Radboudumc - Radboud University Medical Center Nijmegen

Nijmegen, , Netherlands

Site Status

UMC-Academisch Ziekenhuis Utrecht

Utrecht, , Netherlands

Site Status

Medical University Of Gdansk

Gdansk, , Poland

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

Hospital Universitario San Carlos

Madrid, , Spain

Site Status

Complejo Hospitalario de Navarra

Pamplona, , Spain

Site Status

Hospital Universitario de Salamanca

Salamanca, , Spain

Site Status

East Kent Hospitals University NHS Foundation Trust - Queen Elizabeth The Queen Mother Hospita

Margate, Kent, United Kingdom

Site Status

Northampton General Hospital NHS Trust

Cliftonville, Northampton, United Kingdom

Site Status

NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital

Glasgow, , United Kingdom

Site Status

Countries

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Austria Belgium Germany Italy Jordan Netherlands Poland Spain United Kingdom

Other Identifiers

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EORTC-1514-QLG-GCG

Identifier Type: -

Identifier Source: org_study_id

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