NeSST2: The Development of a Noninvasive Short Synacthen Test

NCT ID: NCT03514589

Last Updated: 2024-12-03

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-10-12
• Study Completion Date: 2025-12-01

Brief Summary

Recently there has been concern about the effect of inhaled steroids, routinely used in the treatment of asthma, on the body's ability to produce its natural stress hormone cortisol. Failure of adequate cortisol production in times of stress e.g. illness, can result in serious illness or death. Patients receiving longterm steroid treatment may have reduced levels of cortisol and not be able to produce adequate amounts in times of need, a process called adrenal suppression. Initially it was thought that the absorption of inhaled steroids into the bloodstream would be too low to cause adrenal suppression however high profile deaths followed by a national survey revealed a number of fatal or near fatal cases of adrenal suppression. The vast majority of these were in children. Since then doctors have been encouraged to ensure that children on high doses of inhaled steroids carry a steroid alert card and that the ability of their adrenal glands to produce adequate amounts of cortisol is checked. However it is unknown what dose of inhaled steroids puts one at risk, whether age or gender affects one's risk and when to check the function of the adrenal gland.

The Short Synacthen Test (SST) investigates the ability of the body's adrenal glands to produce cortisol. Presently the SST requires intravenous (i.v) cannulation through which Synacthen is injected to stimulate the adrenal glands and multiple blood samples are collected to assess the response in terms of cortisol production. It is invasive, time consuming and unpleasant for the child. Our project aims to produce a noninvasive alternative to the current SST, with Synacthen given nasally and using saliva to measure the subsequent production of cortisol. A noninvasive test will allow us to establish the first normal ranges for children and determine which children with asthma are at risk of adrenal suppression.

Detailed Description

The success of the nasal administration of a novel formulation of Synacthen to adults was the first step in a work-stream, which aims to develop the clinical applicability of the non-invasive SST in addition to using it as an important research tool. The invasive nature of the current diagnostic test makes large cohort research impracticable. Having gained proof of concept with the initial study we will now go on to gained detailed pharmacokinetic information in adults with the IV comparator of the 250 mcg test in addition to the data already gained for the 1 mcg test. We will test two doses of nasal Synacthen. We will do intra-individual variation work also.

The next stage will then to be to perform pharmacokinetic validation of the nasal Synacthen plus chitosan dose in twenty children in order to establish that the chosen dose, peak cortisol response, bioavailability and pharmacokinetics are similar in the paediatric population. This will require 40 visits to our Childrens' Clinical Research Facility.

In order to obtain the quality of pharmacokinetic data required for commercial regulatory approvals an improved Synacthen assay is required. This work is ongoing in collaboration with ACTH assay experts at the University of Manchester.

Conditions

Adrenal Suppression

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Arm 1

250 mcg IV synacthen

Group Type: ACTIVE_COMPARATOR

nasal Tetracosactide

Intervention Type: DRUG

Bioavailability of nasal synacthen compared to IV comparator

Arm 2

Nasal Synacthen

Group Type: EXPERIMENTAL

IV tetracosactide

Intervention Type: DRUG

Bioavailability of nasal synacthen compared to IV comparator

Interventions

nasal Tetracosactide

Bioavailability of nasal synacthen compared to IV comparator

Intervention Type: DRUG

IV tetracosactide

Bioavailability of nasal synacthen compared to IV comparator

Intervention Type: DRUG

Other Intervention Names

cosyntropin; Synacthen; cosyntropin; synacthen

Eligibility Criteria

Inclusion Criteria

Stage 1b+c:

Exclusion Criteria

Stage 2:

Stage 3:

Stage 4:

1. Past or present history of an endocrinopathy (all stages)

2. Past or present history of asthma (stages 1b+c,2,3)

3. Past or present history of allergic rhinitis (stages 1b+c,2,3)

4. Past or present history of peptic ulcer disease/GI bleed/significant dyspepsia (stages 1b+c,2)

5. Past history of intra-cranial or renal/adrenal pathology (all stages)

6. Presently on any medication (stages 1b+c,2,3)

7. Presently, or within the last 3 months, been prescribed any type of corticosteroid (oral, inhaled, nasal, rectal, intravenous, intramuscular, intra-articular, intra-ocular, topical) (stages 1b+c,2,3)

8. Ever been prescribed a prolonged course of oral corticosteroids (more than 1 month) (stages 1b+c,2,3)

9. Previous adverse reaction (including mild hypersensitivity) to ACTH or Synacthen (all stages)

10. Previous severe allergic reaction or anaphylaxis (all stages)

11. Coryzal symptoms within the last week (and will be asked to report any new symptoms occurring within 24 hours of the test) (all stages)

12. Current smoker (all stages)

13. Body Mass Index less than 18.5 or more than 30kg/m2 (stages 1b+c) outside 3rd to 97th centiles for ages and sex (stage 2)

14. Currently pregnant (stages 2,3,4)

15. Currently anaemic (stages 1b+c,2)

• Minimum Eligible Age: 6 Months
• Maximum Eligible Age: 60 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Sheffield Children's NHS Foundation Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Charlotte Elder

Role: PRINCIPAL_INVESTIGATOR

Investigator

Locations

Sheffield Children's NHS Foundation Trust

Sheffield, Sheffield (South Yorkshire District), United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Central Contacts

Meena Balasubramanian

Role: CONTACT

meena.balasubramanian@nhs.net

Gillian Gatenby

Role: CONTACT

gillian.gatenby@nhs.net

Facility Contacts

Meena Balasubramanian

Role: primary

meena.balasubramanian@nhs.net

Gillian Gatenby

Role: backup

gillian.gatenby@nhs.net

Other Identifiers

SCH/12/043

Identifier Type: -

Identifier Source: org_study_id