The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity

NCT ID: NCT03514342

Last Updated: 2021-06-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 48 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-06-18
• Study Completion Date: 2019-07-01

Brief Summary

This study evaluates the effects of Horner's syndrome on cardiac autonomic nervous activity after interscalene brachial plexus block. Cardiac autonomic nervous activity and bilateral pupil diameters will be measured in a scotopic light condition, 30 minutes after interscalene brachial plexus block under ultrasound guidance and 15 minutes after the subsequent sitting position.

Detailed Description

Stellate ganglia provide sympathetic fibers to the heart. Ipsilateral stellate ganglion block accompanied by interscalene brachial plexus block causes Horner's syndrome presenting with miosis, ptosis, and anhidrosis. The extent of Horner's syndrome can be represented by the difference in pupil diameter between bilateral eyes. Cardiac autonomic nervous activity affected by stellate ganglion block can be measured by calculation of heart rate variability parameters.

Conditions

Brachial Plexus Block; Horner Syndrome; Autonomic Imbalance

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Interscalene brachial plexus block

Ultrasound-guided interscalene brachial plexus block with 25 ml to 30 ml of 0.75% ropivacaine

Interscalene brachial plexus block

Intervention Type: PROCEDURE

Under ultrasound guidance, the 5th to 7th cervical nerve roots are identified between anterior and middle scalene muscles and subsequently blocked.

0.75% ropivacaine

Intervention Type: DRUG

Placement of 25 to 30 ml of 0.75% ropivacaine around the 5th to 7th cervical nerve roots

Interventions

Interscalene brachial plexus block

Under ultrasound guidance, the 5th to 7th cervical nerve roots are identified between anterior and middle scalene muscles and subsequently blocked.

Intervention Type: PROCEDURE

0.75% ropivacaine

Placement of 25 to 30 ml of 0.75% ropivacaine around the 5th to 7th cervical nerve roots

Intervention Type: DRUG

Other Intervention Names

Naropin

Eligibility Criteria

Inclusion Criteria

• American Society of Anesthesiologists physical status 1
• Arthroscopic shoulder surgery under interscalene brachial plexus block

Exclusion Criteria

• Coagulopathy
• Infection at the site of brachial plexus block
• Peripheral neuropathy or neurologic sequelae on the operative limb
• Allergy to local anesthetics or history of allergic shock
• Psychiatric diseases
• Patient refusal
• Difficulty communicating with medical personnel
• Arrhythmias
• Ischemic heart disease
• Hypertension
• Diabetes mellitus
• Thyroid dysfunction
• Conduction abnormalities on electrocardiogram
• Electrolyte imbalance
• Medications affecting cardiac conduction
• Contralateral vocal cord palsy
• Contralateral hemidiaphragmatic paresis or paralysis
• Contralateral pneumothorax or hemothorax

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Research Institute of Medical Science, Daegu Catholic University

UNKNOWN

Sponsor Role: collaborator

Daegu Catholic University Medical Center

OTHER

Sponsor Role: lead

Responsible Party

JongHae Kim

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jong Hae Kim, MD

Role: PRINCIPAL_INVESTIGATOR

Daegu Catholic University Medical Center

Locations

Daegu Catholic University Medical Center

Daegu, , South Korea

Countries

South Korea

Other Identifiers

2018-02

Identifier Type: -

Identifier Source: org_study_id