12-Week Study Assessing Change in Psoriasis Severity and Level of Stress Using TEN

NCT ID: NCT03511755

Last Updated: 2018-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-12

Study Completion Date

2018-07-24

Brief Summary

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This is a 12-Week, multicenter, double-blind, controlled, randomized study assessing change in psoriasis severity and level of stress in patients with moderate to severe psoriasis treated with TEN. Psoriasis severity and stress levels will be measured at Weeks 0, 4, 8 and 12.

Detailed Description

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Conditions

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Psoriasis Stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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TEN 1-11 kHz

Transdermal Electrical Neuromodulator (TEN) waveform pulsed biphasic current (1-11 kHz)

Group Type EXPERIMENTAL

Transdermal Electrical Neuromodulator (TEN)

Intervention Type DEVICE

Thync TEN is a portable, battery-powered, electrical neuromodulation device connected to single-use gel electrode pads that are applied to the base of the neck (C3 to C7).

TEN 1-3 kHz

Transdermal Electrical Neuromodulator (TEN) waveform pulsed biphasic current (1-3 kHz)

Group Type ACTIVE_COMPARATOR

Transdermal Electrical Neuromodulator (TEN)

Intervention Type DEVICE

Thync TEN is a portable, battery-powered, electrical neuromodulation device connected to single-use gel electrode pads that are applied to the base of the neck (C3 to C7).

Interventions

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Transdermal Electrical Neuromodulator (TEN)

Thync TEN is a portable, battery-powered, electrical neuromodulation device connected to single-use gel electrode pads that are applied to the base of the neck (C3 to C7).

Intervention Type DEVICE

Other Intervention Names

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Thync TEN

Eligibility Criteria

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Inclusion Criteria

* Outpatient, male or female of any race, 18 years of age or older.
* Moderate (\>3 to \<10% BSA) with a PASI of at least 6 and less than 12 or severe (≥10% BSA) plaque psoriasis with a minimal PASI score of 12.
* Subject diagnosed with psoriasis at least 6 months prior to entering the study.
* Subjects who have received treatment in the past for psoriasis and are currently untreated or subjects who are on stable treatment for psoriasis that is expected to remain unchanged throughout the entire duration.
* Subjects who have not received psoriasis treatments in the past should be stable in their disease for the last 4 weeks.

Exclusion Criteria

* Guttate, erythrodermic, or pustular psoriasis subtypes.
* Evidence of skin conditions other than psoriasis that would interfere with study-related evaluations of psoriasis.
* Unstable psoriasis or unstable treatment of psoriasis over the entire duration of the study.
* Subjects with moderate psoriasis are not allowed to use concurrent systemic therapies for psoriasis (i.e., phototherapy, orals, biologics, etc.). Topical medications are allowed;
* Subjects with severe psoriasis are allowed to use any concurrent therapy for psoriasis, provided that disease state is stable for ≥2 months and they meet minimum PASI requirements.
* Cardiac pacemaker, implanted defibrillator, or other implanted metallic or electronic device.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ethica Clinical Research Inc.

INDUSTRY

Sponsor Role collaborator

Thync Global, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Site 1

Fremont, California, United States

Site Status

Site 3

San Diego, California, United States

Site Status

Site 2

Santa Monica, California, United States

Site Status

Countries

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United States

Other Identifiers

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THY-002

Identifier Type: -

Identifier Source: org_study_id

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