Trial Outcomes & Findings for Using MC1R Genotype to Impact Melanoma Risk Behavior (NCT NCT03509467)

Results Overview

Self-reported number of hours wearing sunglasses outdoors for the Non-Hispanic White Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

2054 participants

Primary outcome timeframe

12 Months

Results posted on

2025-12-19

Participant Flow

Participant milestones

Participant milestones
Measure	MC1R Average Risk- Control- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk- Control- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk- Control - Hispanic Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.
Overall Study STARTED	227	226	339	342	195	195	262	268
Overall Study COMPLETED	222	225	331	333	184	185	251	257
Overall Study NOT COMPLETED	5	1	8	9	11	10	11	11

Reasons for withdrawal

Reasons for withdrawal
Measure	MC1R Average Risk- Control- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk- Control- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk- Control - Hispanic Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Hispanic Population Post determination of MC1R Genotypes, participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk. All participants received information on sun protection behaviors targeted at children.
Overall Study Withdrawal by Subject	5	1	6	7	10	10	10	10
Overall Study Death	0	0	2	2	1	0	1	0
Overall Study Proxy Withdrawal	0	0	0	0	0	0	0	1

Baseline Characteristics

Using MC1R Genotype to Impact Melanoma Risk Behavior

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Average Risk- Control- Hispanic Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Hispanic Population n=195 Participants Participants in the average risk precision prevention arm (Intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Hispanic Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (Control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Hispanic Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	Total n=2054 Participants Total of all reporting groups
Age, Customized Age <=18 years	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	0 Participants n=6 Participants	0 Participants n=195 Participants	0 Participants n=585 Participants	0 Participants n=19829 Participants	0 Participants n=77547 Participants
Age, Customized Between 18 and 65 years	189 Participants n=8 Participants	190 Participants n=6 Participants	277 Participants n=6 Participants	300 Participants n=9 Participants	163 Participants n=6 Participants	172 Participants n=195 Participants	227 Participants n=585 Participants	236 Participants n=19829 Participants	1754 Participants n=77547 Participants
Age, Customized > =65 years	38 Participants n=8 Participants	36 Participants n=6 Participants	62 Participants n=6 Participants	42 Participants n=9 Participants	32 Participants n=6 Participants	22 Participants n=195 Participants	35 Participants n=585 Participants	31 Participants n=19829 Participants	298 Participants n=77547 Participants
Age, Customized Unknown	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	0 Participants n=6 Participants	1 Participants n=195 Participants	0 Participants n=585 Participants	1 Participants n=19829 Participants	2 Participants n=77547 Participants
Sex/Gender, Customized Male	115 Participants n=8 Participants	110 Participants n=6 Participants	164 Participants n=6 Participants	174 Participants n=9 Participants	55 Participants n=6 Participants	58 Participants n=195 Participants	66 Participants n=585 Participants	79 Participants n=19829 Participants	821 Participants n=77547 Participants
Sex/Gender, Customized Female	112 Participants n=8 Participants	116 Participants n=6 Participants	175 Participants n=6 Participants	168 Participants n=9 Participants	138 Participants n=6 Participants	134 Participants n=195 Participants	193 Participants n=585 Participants	186 Participants n=19829 Participants	1222 Participants n=77547 Participants
Sex/Gender, Customized Unknown	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	2 Participants n=6 Participants	3 Participants n=195 Participants	3 Participants n=585 Participants	3 Participants n=19829 Participants	11 Participants n=77547 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	195 Participants n=6 Participants	195 Participants n=195 Participants	262 Participants n=585 Participants	268 Participants n=19829 Participants	920 Participants n=77547 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	227 Participants n=8 Participants	226 Participants n=6 Participants	339 Participants n=6 Participants	342 Participants n=9 Participants	0 Participants n=6 Participants	0 Participants n=195 Participants	0 Participants n=585 Participants	0 Participants n=19829 Participants	1134 Participants n=77547 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	0 Participants n=6 Participants	0 Participants n=195 Participants	0 Participants n=585 Participants	0 Participants n=19829 Participants	0 Participants n=77547 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	1 Participants n=6 Participants	1 Participants n=195 Participants	2 Participants n=585 Participants	4 Participants n=19829 Participants	8 Participants n=77547 Participants
Race (NIH/OMB) Asian	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	0 Participants n=6 Participants	0 Participants n=195 Participants	1 Participants n=585 Participants	0 Participants n=19829 Participants	1 Participants n=77547 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	0 Participants n=6 Participants	0 Participants n=195 Participants	0 Participants n=585 Participants	0 Participants n=19829 Participants	0 Participants n=77547 Participants
Race (NIH/OMB) Black or African American	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	15 Participants n=6 Participants	15 Participants n=195 Participants	6 Participants n=585 Participants	13 Participants n=19829 Participants	49 Participants n=77547 Participants
Race (NIH/OMB) White	227 Participants n=8 Participants	226 Participants n=6 Participants	339 Participants n=6 Participants	342 Participants n=9 Participants	149 Participants n=6 Participants	152 Participants n=195 Participants	221 Participants n=585 Participants	213 Participants n=19829 Participants	1869 Participants n=77547 Participants
Race (NIH/OMB) More than one race	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	5 Participants n=6 Participants	4 Participants n=195 Participants	4 Participants n=585 Participants	9 Participants n=19829 Participants	22 Participants n=77547 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=8 Participants	0 Participants n=6 Participants	0 Participants n=6 Participants	0 Participants n=9 Participants	25 Participants n=6 Participants	23 Participants n=195 Participants	28 Participants n=585 Participants	29 Participants n=19829 Participants	105 Participants n=77547 Participants
Region of Enrollment Puerto Rico	0 participants n=8 Participants	0 participants n=6 Participants	0 participants n=6 Participants	0 participants n=9 Participants	93 participants n=6 Participants	93 participants n=195 Participants	123 participants n=585 Participants	124 participants n=19829 Participants	433 participants n=77547 Participants
Region of Enrollment United States	227 participants n=8 Participants	226 participants n=6 Participants	339 participants n=6 Participants	342 participants n=9 Participants	102 participants n=6 Participants	102 participants n=195 Participants	139 participants n=585 Participants	144 participants n=19829 Participants	1621 participants n=77547 Participants

PRIMARY outcome

Timeframe: Baseline

Self-reported average hours spent outside during weekdays for the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - NHW - Baseline	1.27 Hours Standard Error 0.03	1.30 Hours Standard Error 0.03	1.26 Hours Standard Error 0.03	1.29 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: 12 months

Self-reported average hours spent outside during weekdays for the Non-Hispanic White Population after they received the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - NHW - After Intervention	1.09 Hours Standard Error 0.04	1.18 Hours Standard Error 0.06	1.09 Hours Standard Error 0.05	1.05 Hours Standard Error 0.05

PRIMARY outcome

Timeframe: Baseline

Self-reported average hours spent outside during weekends for the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - NHW - Baseline	2.17 Hours Standard Error 0.04	2.25 Hours Standard Error 0.07	2.25 Hours Standard Error 0.04	2.30 Hours Standard Error 0.07

PRIMARY outcome

Timeframe: 12 Months

Self-reported average hours spent outside during weekends for the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - NHW - After Intervention	2.00 Hours Standard Error 0.08	2.08 Hours Standard Error 0.07	1.89 Hours Standard Error 0.07	1.89 Hours Standard Error 0.07

PRIMARY outcome

Timeframe: Baseline

Self-reported number of red or painful sunburns for the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - NHW - Baseline	0.60 Sunburns Standard Error 0.03	0.66 Sunburns Standard Error 0.04	0.83 Sunburns Standard Error 0.06	0.85 Sunburns Standard Error 0.06

PRIMARY outcome

Timeframe: 12 Months

Self-reported number of red or painful sunburns for the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - NHW - After Intervention	0.29 Sunburns Standard Error 0.04	0.20 Sunburns Standard Error 0.04	0.27 Sunburns Standard Error 0.04	0.28 Sunburns Standard Error 0.05

PRIMARY outcome

Timeframe: Baseline

Self-reported number on a scale from 1=never to 5=always for outdoor intentional tanning for the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - NHW - Baseline	2.01 score on a scale Standard Error 0.06	2.03 score on a scale Standard Error 0.06	1.96 score on a scale Standard Error 0.02	1.95 score on a scale Standard Error 0.02

PRIMARY outcome

Timeframe: 12 Months

Self-reported number on a scale from 1=never to 5=always outdoor intentional tanning for the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - NHW - After Intervention	1.79 score on a scale Standard Error 0.07	1.82 score on a scale Standard Error 0.07	1.70 score on a scale Standard Error 0.04	1.71 score on a scale Standard Error 0.03

PRIMARY outcome

Timeframe: Baseline

Proportion who practiced wearing a hat for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Proportion of Participants Wearing a Hat - NHW - Baseline	0.20 proportion of participants Standard Error 0.03	0.17 proportion of participants Standard Error 0.03	0.25 proportion of participants Standard Error 0.03	0.27 proportion of participants Standard Error 0.03

PRIMARY outcome

Timeframe: 12 Months

Proportion who practiced wearing a hat for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Proportion of Participants Wearing a Hat - NHW - After Intervention	0.24 proportion of participants Standard Error 0.04	0.29 proportion of participants Standard Error 0.04	0.33 proportion of participants Standard Error 0.03	0.32 proportion of participants Standard Error 0.03

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours for seeking shade or using an umbrella outdoors for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - NHW - Baseline	0.35 Hours Standard Error 0.04	0.27 Hours Standard Error 0.04	0.33 Hours Standard Error 0.03	0.34 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: 12 Months

Self-reported number of hours for seeking shade or using an umbrella outdoors for the Non-Hispanic White Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - NHW - After Intervention	0.34 Hours Standard Error 0.04	0.35 Hours Standard Error 0.04	0.35 Hours Standard Error 0.03	0.43 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing a shirt with sleeves outdoors for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - NHW - Baseline	0.72 Hours Standard Error 0.04	0.70 Hours Standard Error 0.04	0.68 Hours Standard Error 0.03	0.70 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing a shirt with sleeves outdoors for the Non-Hispanic White Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - NHW - After Intervention	0.71 Hours Standard Error 0.03	0.72 Hours Standard Error 0.03	0.67 Hours Standard Error 0.03	0.75 Hours Standard Error 0.02

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing sunglasses outdoors for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - NHW - Baseline	0.76 Hours Standard Error 0.03	0.75 Hours Standard Error 0.04	0.66 Hours Standard Error 0.03	0.70 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing sunglasses outdoors for the Non-Hispanic White Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - NHW - After Intervention	0.77 Hours Standard Error 0.03	0.76 Hours Standard Error 0.04	0.70 Hours Standard Error 0.03	0.73 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing sunscreen outdoors for the Non-Hispanic White Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - NHW - Baseline	0.36 Hours Standard Error 0.04	0.28 Hours Standard Error 0.04	0.36 Hours Standard Error 0.04	0.40 Hours Standard Error 0.04

PRIMARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing sunscreen outdoors for the Non-Hispanic White Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - NHW - After Intervention	0.36 Hours Standard Error 0.04	0.30 Hours Standard Error 0.04	0.42 Hours Standard Error 0.03	0.38 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: Baseline

Participants with at least one indoor intentional tanning session for the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=227 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=226 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=339 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=342 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Participants With Indoor Intentional Tanning - NHW - Baseline	10 Participants	12 Participants	18 Participants	7 Participants

PRIMARY outcome

Timeframe: 12 Months

Participants with at least one indoor intentional tanning session for the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=222 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=225 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=331 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=333 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Participants With Indoor Intentional Tanning - NHW - After Intervention	4 Participants	9 Participants	15 Participants	7 Participants

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of weekday sun exposure for the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - Hispanic Population Baseline	1.70 Hours Standard Error 0.11	1.60 Hours Standard Error 0.11	1.74 Hours Standard Error 0.06	1.65 Hours Standard Error 0.05

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of weekday sun exposure of the Hispanic population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - Hispanic Population After Intervention	1.38 Hours Standard Error 0.10	1.28 Hours Standard Error 0.10	1.38 Hours Standard Error 0.10	1.45 Hours Standard Error 0.10

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of weekend sun exposure for the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - Hispanic Population - Baseline	2.04 Hours Standard Error 0.12	1.88 Hours Standard Error 0.11	2.05 Hours Standard Error 0.07	1.95 Hours Standard Error 0.07

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of weekend sun exposure for the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - Hispanic Population - After Intervention	1.57 Hours Standard Error 0.10	1.62 Hours Standard Error 0.11	1.67 Hours Standard Error 0.07	1.57 Hours Standard Error 0.08

PRIMARY outcome

Timeframe: Baseline

Self-reported number of Sunburns for the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - Hispanic Population - Baseline	0.42 Sunburns Standard Error 0.07	0.52 Sunburns Standard Error 0.07	0.47 Sunburns Standard Error 0.05	0.56 Sunburns Standard Error 0.05

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of Sunburns for the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - Hispanic Population - After Intervention	0.10 Sunburns Standard Error 0.04	0.15 Sunburns Standard Error 0.05	0.21 Sunburns Standard Error 0.04	0.21 Sunburns Standard Error 0.04

PRIMARY outcome

Timeframe: Baseline

Self-reported number on a scale from 1=never to 5=always intentional tanning for the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - Hispanic Population - Baseline	1.64 score on a scale Standard Error 0.06	1.75 score on a scale Standard Error 0.07	1.64 score on a scale Standard Error 0.05	1.66 score on a scale Standard Error 0.05

PRIMARY outcome

Timeframe: 9 Months

Self-reported number on a scale from 1=never to 5=always outdoor intentional tanning for the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - Hispanic Population - After Intervention	1.48 score on a scale Standard Error 0.05	1.49 score on a scale Standard Error 0.07	1.49 score on a scale Standard Error 0.05	1.48 score on a scale Standard Error 0.04

PRIMARY outcome

Timeframe: Baseline

Proportion who practiced wearing a hat Often to Always for the Hispanic Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Proportion of Participants Wearing a Hat - Hispanic Population - Baseline	0.15 proportion of participants Standard Error 0.03	0.12 proportion of participants Standard Error 0.03	0.25 proportion of participants Standard Error 0.04	0.17 proportion of participants Standard Error 0.03

PRIMARY outcome

Timeframe: 9 months

Proportion who practiced wearing a hat Often to Always for the Hispanic Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Proportion of Participants Wearing a Hat - Hispanic Population - After Intervention	0.19 proportion of participants Standard Error 0.04	0.17 proportion of participants Standard Error 0.03	0.32 proportion of participants Standard Error 0.05	0.23 proportion of participants Standard Error 0.04

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of seeking shade or using an umbrella for the Hispanic Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - Hispanic Population - Baseline	0.42 Hours Standard Error 0.04	0.35 Hours Standard Error 0.03	0.43 Hours Standard Error 0.04	0.38 Hours Standard Error 0.03

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of seeking shade or using an umbrella for the Hispanic Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - Hispanic Population - After Intervention	0.52 Hours Standard Error 0.04	0.46 Hours Standard Error 0.04	0.50 Hours Standard Error 0.06	0.53 Hours Standard Error 0.06

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of wearing a shirt for the Hispanic Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Hispanic Population - Baseline	0.66 Hours Standard Error 0.04	0.65 Hours Standard Error 0.04	0.70 Hours Standard Error 0.04	0.67 Hours Standard Error 0.04

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of wearing a shirt with sleeves outdoors for the Hispanic Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Hispanic Population - After Intervention	0.65 Hours Standard Error 0.04	0.63 Hours Standard Error 0.04	0.68 Hours Standard Error 0.04	0.72 Hours Standard Error 0.04

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of wearing sunglasses for the Hispanic Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Hispanic Population - Baseline	0.52 Hours Standard Error 0.04	0.46 Hours Standard Error 0.04	0.54 Hours Standard Error 0.05	0.51 Hours Standard Error 0.04

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of wearing sunglasses for the Hispanic Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Hispanic Population - After Intervention	0.52 Hours Standard Error 0.04	0.49 Hours Standard Error 0.04	0.54 Hours Standard Error 0.12	0.66 Hours Standard Error 0.10

PRIMARY outcome

Timeframe: Baseline

Self-reported number of hours of wearing sunscreen for the Hispanic Population. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic Population - Baseline	0.24 Hours Standard Error 0.03	0.16 Hours Standard Error 0.03	0.13 Hours Standard Error 0.02	0.15 Hours Standard Error 0.02

PRIMARY outcome

Timeframe: 9 Months

Self-reported number of hours of wearing sunscreen for the Hispanic Population after receiving the intervention. This is a population predicted marginal proportion estimated by running a generalized estimating equation with the outcome modeled as a repeated binomial distribution (practiced the behavior often to always vs. sometimes, rarely, or never measured at both follow-ups) and using a logit link function. The model covariates included the baseline measure, any imbalanced baseline measures, predictors of missingness, and predictors of outcome.

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic Population - After Intervention	0.25 Hours Standard Error 0.04	0.19 Hours Standard Error 0.03	0.13 Hours Standard Error 0.04	0.24 Hours Standard Error 0.06

PRIMARY outcome

Timeframe: Baseline

Participants with at least one indoor intentional tanning session for the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=195 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=195 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=262 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=268 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Participants With Intentional Indoor Tanning - Hispanic Population - Baseline	4 Participants	6 Participants	5 Participants	7 Participants

PRIMARY outcome

Timeframe: 9 Months

Participants with at least one indoor intentional tanning session for the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=184 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=185 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=251 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=257 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Participants With Intentional Indoor Tanning - Hispanic Population - After Intervention	3 Participants	2 Participants	6 Participants	5 Participants

SECONDARY outcome

Timeframe: Baseline

Self-reported average hours spent outside during weekdays among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - NHW Children - Baseline	1.31 Hours Standard Error 0.09	1.50 Hours Standard Error 0.10	1.42 Hours Standard Error 0.08	1.40 Hours Standard Error 0.06

SECONDARY outcome

Timeframe: 12 months

Self-reported average hours spent outside during weekdays among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - NHW Children - After Intervention	1.29 Hours Standard Error 0.10	1.23 Hours Standard Error 0.14	1.34 Hours Standard Error 0.10	1.47 Hours Standard Error 0.10

SECONDARY outcome

Timeframe: Baseline

Self-reported average hours spent outside during weekends among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - NHW Children - Baseline	2.23 Hours Standard Error 0.07	2.29 Hours Standard Error 0.09	2.33 Hours Standard Error 0.08	2.26 Hours Standard Error 0.06

SECONDARY outcome

Timeframe: 12 Months

Self-reported average hours spent outside during weekends among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - NHW Children - After Intervention	2.36 Hours Standard Error 0.17	2.10 Hours Standard Error 0.17	2.28 Hours Standard Error 0.14	2.24 Hours Standard Error 0.14

SECONDARY outcome

Timeframe: Baseline

Self-reported number of red or painful sunburns among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - NHW Children - Baseline	0.31 Sunburns Standard Error 0.08	0.48 Sunburns Standard Error 0.13	0.32 Sunburns Standard Error 0.04	0.37 Sunburns Standard Error 0.06

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of red or painful sunburns among the children of the participants in the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - NHW Children - After Intervention	0.25 Sunburns Standard Error 0.11	0.16 Sunburns Standard Error 0.09	0.26 Sunburns Standard Error 0.04	0.10 Sunburns Standard Error 0.05

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours for outdoor intentional tanning among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor International Tanning - NHW Children - Baseline	1.09 Hours Standard Error 0.06	1.13 Hours Standard Error 0.09	1.16 Hours Standard Error 0.03	1.10 Hours Standard Error 0.03

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours for outdoor intentional tanning among the children of the participants in the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - NHW Children - After Intervention	1.06 Hours Standard Error 0.05	0.99 Hours Standard Error 0.05	1.03 Hours Standard Error 0.03	1.06 Hours Standard Error 0.01

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing a hat outdoors among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Hat - NHW Children - Baseline	0.24 Hours Standard Error 0.09	0.11 Hours Standard Error 0.05	0.07 Hours Standard Error 0.02	0.09 Hours Standard Error 0.03

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours for wearing a hat outdoors among the children of the participants in the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Hat - NHW Children - After Intervention	0.08 Hours Standard Error 0.08	0.02 Hours Standard Error 0.03	0.07 Hours Standard Error 0.05	0.05 Hours Standard Error 0.04

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours for seeking shade or using an umbrella outdoors among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - NHW Children - Baseline	0.12 Hours Standard Error 0.07	0.19 Hours Standard Error 0.17	0.14 Hours Standard Error 0.04	0.15 Hours Standard Error 0.05

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours for seeking shade or using an umbrella outdoors among the children of the participants in the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - NHW Children - After Intervention	0.49 Hours Standard Error 0.26	0.17 Hours Standard Error 0.11	0.07 Hours Standard Error 0.04	0.18 Hours Standard Error 0.06

SECONDARY outcome

Timeframe: Baseline

Average Risk Participants children who wore a shirt with sleeves outdoors among the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Average Risk NHW Children - Baseline	22 Participants	16 Participants	—	—

SECONDARY outcome

Timeframe: 12 Month

Average Risk Participants children who wore a shirt with sleeves outdoors among the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Average Risk NHW Children - After Intervention	25 Participants	21 Participants	—	—

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing a shirt with sleeves outdoors among the children of the participants in the Non-Hispanic White High Risk Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - High Risk NHW Children - Baseline	0.91 Hours Standard Error 0.03	0.84 Hours Standard Error 0.04	—	—

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing a shirt with sleeves outdoors among the children of the participants in the Non-Hispanic White High Risk Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - High Risk NHW Children - After Intervention	0.85 Hours Standard Error 0.06	0.96 Hours Standard Error 0.03	—	—

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing sunglasses outdoors among the children of the participants in the Non-Hispanic White Average Risk Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Average Risk NHW Children - Baseline	0.04 Hours Standard Error 0.03	0.04 Hours Standard Error 0.03	—	—

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing sunglasses outdoors among the children of the participants in the Non-Hispanic White Average Risk Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Average Risk NHW Children - After Intervention	0.01 Hours Standard Error 0.02	0.04 Hours Standard Error 0.06	—	—

SECONDARY outcome

Timeframe: Baseline

Children of the participants in the Non-Hispanic White High Risk Population who wore sunglasses outdoors

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses -High Risk NHW Children - Baseline	3 Participants	7 Participants	—	—

SECONDARY outcome

Timeframe: 12 Months

Children of the participants in the Non-Hispanic White High Risk Population who wore sunglasses outdoors after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - High Risk NHW Children - After Intervention	4 Participants	7 Participants	—	—

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours for wearing sunscreen outdoors among the children of the participants in the Non-Hispanic White Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - NHW Children - Baseline	0.71 Hours Standard Error 0.08	0.66 Hours Standard Error 0.11	0.83 Hours Standard Error 0.04	0.88 Hours Standard Error 0.04

SECONDARY outcome

Timeframe: 12 Months

Self-reported number of hours wearing sunscreen outdoors among the children of the participants in the Non-Hispanic White Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=25 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=21 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=49 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=46 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - NHW Children - After Intervention	0.70 Hours Standard Error 0.12	0.44 Hours Standard Error 0.24	0.69 Hours Standard Error 0.11	0.86 Hours Standard Error 0.06

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of weekday sun exposure among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - Hispanic Children Population Baseline	1.48 Hours Standard Error 0.01	1.49 Hours Standard Error 0.02	1.73 Hours Standard Error 0.23	1.53 Hours Standard Error 0.18

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of weekday sun exposure among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekday Sun Exposure - Hispanic Children Population After Intervention	1.33 Hours Standard Error 0.09	1.04 Hours Standard Error 0.28	2.46 Hours Standard Error 0.29	0.90 Hours Standard Error 0.22

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of weekend sun exposure among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - Hispanic Children Population - Baseline	1.80 Hours Standard Error 0.15	2.18 Hours Standard Error 0.13	1.87 Hours Standard Error 0.08	1.88 Hours Standard Error 0.08

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of weekend sun exposure among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Weekend Sun Exposure - Hispanic Children Population - After Intervention	1.56 Hours Standard Error 0.07	1.48 Hours Standard Error 0.12	2.18 Hours Standard Error 0.30	0.84 Hours Standard Error 0.39

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of sun protection behaviors among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sun Protection Behaviors - Hispanic Children Population - Baseline	1.44 Hours Standard Error 0.16	1.51 Hours Standard Error 0.14	1.50 Hours Standard Error 0.03	1.55 Hours Standard Error 0.02

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of sun protection behaviors among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sun Protection Behaviors - Hispanic Children Population - After Intervention	1.21 Hours Standard Error 0.28	1.68 Hours Standard Error 0.23	1.13 Hours Standard Error 0.17	1.98 Hours Standard Error 0.31

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of outdoor intentional tanning among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - Hispanic Children Population - Baseline	1.43 Hours Standard Error 0.09	1.39 Hours Standard Error 0.09	1.24 Hours Standard Error 0.03	1.22 Hours Standard Error 0.02

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of outdoor intentional tanning among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Outdoor Intentional Tanning - Hispanic Children Population - After Intervention	0.93 Hours Standard Error .39	1.64 Hours Standard Error 0.11	1.35 Hours Standard Error 0.15	1.06 Hours Standard Error 0.12

SECONDARY outcome

Timeframe: Baseline

Self-reported number of Sunburns among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - Hispanic Children Population - Baseline	0.53 Sunburns Standard Error 0.02	0.54 Sunburns Standard Error 0.02	0.29 Sunburns Standard Error 0.07	0.20 Sunburns Standard Error 0.10

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of Sunburns among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Sunburns - Hispanic Children Population - After Intervention	0.53 Sunburns Standard Error 0.02	-0.44 Sunburns Standard Error 0.64	1.21 Sunburns Standard Error 0.59	-0.07 Sunburns Standard Error 0.11

SECONDARY outcome

Timeframe: Baseline

Children of participants in the Hispanic Population who wore a hat before receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Hat - Hispanic Children Population - Baseline	1 Participants	1 Participants	2 Participants	7 Participants

SECONDARY outcome

Timeframe: 9 months

Children of participants in the Hispanic Population who wore a hat after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Hat - Hispanic Children Population - After Intervention	0 Participants	0 Participants	2 Participants	4 Participants

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of seeking shade or using an umbrella among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - Hispanic Children Population - Baseline	0.30 Hours Standard Error 0.09	0.16 Hours Standard Error 0.07	0.32 Hours Standard Error 0.08	0.32 Hours Standard Error 0.07

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of seeking shade or using an umbrella among the children of the participants in the Hispanic Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Seeking Shade - Hispanic Children Population - After Intervention	0.45 Hours Standard Error 0.19	0.37 Hours Standard Error 0.20	0.52 Hours Standard Error 0.15	0.46 Hours Standard Error 0.13

SECONDARY outcome

Timeframe: Baseline

Children of the participants in the Hispanic Average Risk Population who reported wearing a shirt with sleeves outdoors

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Average Risk Hispanic Children Population - Baseline	17 Participants	20 Participants	—	—

SECONDARY outcome

Timeframe: 9 Months

Children of the participants in the Hispanic Average Risk Population who reported wearing a shirt with sleeves outdoors, after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Hispanic Children Population - After Intervention	7 Participants	7 Participants	—	—

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of wearing a shirt among the children of the participants in the Hispanic Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Hispanic Children High Risk Population - Baseline	0.61 Hours Standard Error 0.09	0.68 Hours Standard Error 0.07	—	—

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of wearing a shirt with sleeves outdoors among the children of the participants in the Hispanic High Risk Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing a Shirt - Hispanic Children High Risk Population - After Intervention	0.62 Hours Standard Error 0.10	0.69 Hours Standard Error 0.10	—	—

SECONDARY outcome

Timeframe: Baseline

Children of the participants in the Hispanic Population who reported wearing sunglasses

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Hispanic Children Population - Baseline	1 Participants	1 Participants	1 Participants	2 Participants

SECONDARY outcome

Timeframe: 9 Months

Children of the participants in the Hispanic Population who reported wearing sunglasses, after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunglasses - Hispanic Children Population - After Intervention	0 Participants	1 Participants	0 Participants	1 Participants

SECONDARY outcome

Timeframe: Baseline

Children of the participants in the Hispanic Average Risk Population wo reported wearing sunscreen

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic Children Average Risk Population - Baseline	8 Participants	9 Participants	—	—

SECONDARY outcome

Timeframe: 9 Months

Children of the participants in the Hispanic Average Risk Population wo reported wearing sunscreen, after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=26 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=27 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic Children Population - After Intervention	2 Participants	3 Participants	—	—

SECONDARY outcome

Timeframe: Baseline

Self-reported number of hours of wearing sunscreen among the children of the participants in the Hispanic High Risk Population

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic Children High Risk Population - Baseline	0.32 Hours Standard Error 0.08	0.39 Hours Standard Error 0.08	—	—

SECONDARY outcome

Timeframe: 9 Months

Self-reported number of hours of wearing sunscreen among the children of the participants in the Hispanic High Risk Population after receiving the intervention

Outcome measures

Outcome measures
Measure	MC1R Average Risk- Control- Non-Hispanic White Population n=31 Participants Post determination of MC1R Genotypes, participants in the average risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Average Risk - Intervention- Non-Hispanic White Population n=41 Participants Participants in the average risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.	MC1R Higher Risk- Control - Non-Hispanic White Population Post determination of MC1R Genotypes, participants in the higher risk standard arm (control) received mailed materials containing information on (1) melanoma and skin cancer; and (2) melanoma prevention behaviors recommended by the American Academy of Dermatology. All participants received information on sun protection behaviors targeted at children.	MC1R Higher Risk - Intervention- Non-Hispanic White Population Participants in the higher risk precision prevention arm (intervention) received mailed materials containing information on: (1) melanoma and skin cancer; (2) genetic risk for melanoma; (3) MC1R and its role in developing melanoma, their MC1R risk group, and interpretation of risk information; and (4) melanoma prevention behaviors in the context of genetic risk.
Wearing Sunscreen - Hispanic High Risk Children Population - After Intervention	0.29 Hours Standard Error 0.12	0.35 Hours Standard Error 0.13	—	—

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Peter Kanetsky, PhD, MPH

Moffitt Cancer Center

Phone: 813-745-3988

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place