Durability Extension Study to Assess Clinical Activity and Safety of Enobosarm (GTx-024) in Stress Urinary Incontinence

NCT ID: NCT03508648

Last Updated: 2023-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-28

Study Completion Date

2018-09-21

Brief Summary

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The study will enroll only from the first 225 subjects who were randomly assigned to treatment in G201002 (irrespective of the treatment allocation, i.e., GTx-024 or placebo) and who have completed the 12-week treatment period and 16-week durability period to assess the long-term durability of response to GTx-024 on SUI symptoms. The extension study will follow subjects for an additional 20 weeks to help better assess the durability of response in these subjects and will provide additional efficacy and safety data for the subjects. Subjects will not be provided with any study treatments and will be off-drug during this extension study.

Detailed Description

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Conditions

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Stress Urinary Incontinence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Matching Placebo

Subjects previously enrolled in the placebo arm of study G201002.

Group Type PLACEBO_COMPARATOR

Matching Placebo

Intervention Type DRUG

Subjects will not be provided with any study treatments and will be off-drug during this extension study. Intervention was administered during study G201002.

1 mg GTx-024

Subjects previously enrolled in the 1 mg GTx-024 arm of study G201002.

Group Type ACTIVE_COMPARATOR

GTx-024

Intervention Type DRUG

Subjects will not be provided with any study treatments and will be off-drug during this extension study. Intervention was administered during study G201002.

3 mg GTx-024

Subjects previously enrolled in the 3 mg GTx-024 arm of study G201002.

Group Type ACTIVE_COMPARATOR

GTx-024

Intervention Type DRUG

Subjects will not be provided with any study treatments and will be off-drug during this extension study. Intervention was administered during study G201002.

Interventions

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GTx-024

Subjects will not be provided with any study treatments and will be off-drug during this extension study. Intervention was administered during study G201002.

Intervention Type DRUG

Matching Placebo

Subjects will not be provided with any study treatments and will be off-drug during this extension study. Intervention was administered during study G201002.

Intervention Type DRUG

Other Intervention Names

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enobosarm

Eligibility Criteria

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Inclusion Criteria

* Be one of the first 225 subjects who were randomly assigned to treatment in G201002 (Phase 2 study) and have completed the 12-week treatment and 16-week durability periods
* Be able to read, understand, and provide written, dated informed consent prior to enrollment in the current study (within 2 weeks of completing G201002) and be likely to comply with the study protocol and communicate with study personnel about AEs and other clinically important information
* Agree to maintain a stable dose of any medication known to affect lower urinary tract function, including but not limited to anticholinergics, tricyclic antidepressants, beta-3 adrenergic agonists, or α-adrenergic blockers, throughout the duration of the study

Exclusion Criteria

* Starts any new treatment (medication, pelvic floor physical therapy, or other treatment known to impact the pelvic floor) after completing G201002 that is known or suspected to affect lower urinary tract function, including vaginal rejuvenation
* Has a current or past history of any physical condition that, in the investigator's opinion, might put the subject at risk or interfere with interpretation of study results
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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GTx

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kenneth Peters, MD

Role: PRINCIPAL_INVESTIGATOR

Professor & Chair, Department of Urology, Oakland University Wm. Beaumont School of Medicine

Locations

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Urology Center of Alabama

Homewood, Alabama, United States

Site Status

Coastal Clinical Research Inc

Mobile, Alabama, United States

Site Status

Alaska Clinical Research Center

Anchorage, Alaska, United States

Site Status

Genitourinary Surgical Consultants

Denver, Colorado, United States

Site Status

Urology Associates Research

Englewood, Colorado, United States

Site Status

Women's Health Specialty Care

Farmington, Connecticut, United States

Site Status

Coastal Connecticut Research, LLC

New London, Connecticut, United States

Site Status

South Florida Medical Research

Aventura, Florida, United States

Site Status

Tampa Bay Medical Research Inc

Clearwater, Florida, United States

Site Status

Midland Florida Clinical Research Center LLC

DeLand, Florida, United States

Site Status

Medical Research of Florida

Miami, Florida, United States

Site Status

Clinical Research Center of Florida

Pompano Beach, Florida, United States

Site Status

Mount Vernon Clinical Research LLC

Sandy Springs, Georgia, United States

Site Status

Clinical Research Prime

Idaho Falls, Idaho, United States

Site Status

Idaho Urologic Institue

Meridian, Idaho, United States

Site Status

First Urology PSC

Jeffersonville, Indiana, United States

Site Status

Iowa Clinic

West Des Moines, Iowa, United States

Site Status

DelRicht Clinical Research, LLC

New Orleans, Louisiana, United States

Site Status

Regional Urology

Shreveport, Louisiana, United States

Site Status

Chesapeake Urology Associates PA

Hanover, Maryland, United States

Site Status

Boston Clinical Trials

Boston, Massachusetts, United States

Site Status

Bay State Clinical Trials

Watertown, Massachusetts, United States

Site Status

Beyer Research

Kalamazoo, Michigan, United States

Site Status

William Beaumont Hospital Urology Research

Royal Oak, Michigan, United States

Site Status

Women's Clinic of Lincoln

Lincoln, Nebraska, United States

Site Status

Sheldon J Freedman MD Ltd

Las Vegas, Nevada, United States

Site Status

Premier Urology Group, LL

Edison, New Jersey, United States

Site Status

Lawrence Obs Gyn clinical Research

Lawrenceville, New Jersey, United States

Site Status

Delaware Valley Urology

Mount Laurel, New Jersey, United States

Site Status

Accumed Research Associates

Garden City, New York, United States

Site Status

Manhattan Medical Research Practice PLLC

New York, New York, United States

Site Status

Circuit Clinical

West Seneca, New York, United States

Site Status

American Health Research Inc

Charlotte, North Carolina, United States

Site Status

Eastern Carolina Women's

New Bern, North Carolina, United States

Site Status

The Urology Group

Cincinnati, Ohio, United States

Site Status

Aventiv Research

Columbus, Ohio, United States

Site Status

Institute for Female Pelvic Medicine

Allentown, Pennsylvania, United States

Site Status

Urologic Consultants of Southeastern PA LLP

Bala-Cynwyd, Pennsylvania, United States

Site Status

University of Pennsylvania Health System

Philadelphia, Pennsylvania, United States

Site Status

Coastal Carolina Research Center

Mt. Pleasant, South Carolina, United States

Site Status

The Jackson Clinic

Jackson, Tennessee, United States

Site Status

Elligo - Austin Area OBGYN

Austin, Texas, United States

Site Status

Urology Clinics of North Texas

Dallas, Texas, United States

Site Status

Urology San Antonio Research PA

San Antonio, Texas, United States

Site Status

Synexus Clinical Research Advantage, Inc. - Wasatch Peak Family Practice

Layton, Utah, United States

Site Status

Seattle Womens: Health, Research, Gynocology

Seattle, Washington, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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G201003

Identifier Type: -

Identifier Source: org_study_id

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