The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments

NCT ID: NCT03493880

Last Updated: 2018-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-01

Study Completion Date

2025-09-01

Brief Summary

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Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer. With the increasing application of preoperative treatments (chemotherapy and chemoradiotherapy), the issues concerning how are the immuno-nutrition index be altered under the effects of perioperative treatments and what are the clinical values of these index should be clarified.

Detailed Description

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The immune (systemic inflammation) index includes:

NLR (Neutrophil-to-Lymphocyte Ratio); PLR (Platelet-to-Lymphocyte Ratio); SII (Systemic Immune-Inflammation Index); GPS (Glasgow Prognostic Score); mGPS (modified Glasgow Prognostic Score); PI (Prognostic Index);

The nutrition index includes:

NRS2002; PNI (Prognostic Nutrition Index);

Conditions

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Gastric Cancer Neoadjuvant Chemotherapy Neoadjuvant Chemoradiotherapy Systemic Inflammatory Response Syndrome (SIRS) Nutrition Aspect of Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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naCT

Advanced gastric cancer or esophagogastric cancer receiving neoadjuvant (preoperative) chemotherapy.

No interventions assigned to this group

naCRT

Advanced gastric cancer or esophagogastric cancer receiving neoadjuvant (preoperative) chemoradiotherapy.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed adenocarcinoma
* Received neoadjuvant (preoperative) chemotherapy or chemoradiotherapy
* Diagnosed clinical advanced gastric cancer or esophagogastric cancer

Exclusion Criteria

* Lack of immuno-nutrition data
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University

OTHER

Sponsor Role lead

Responsible Party

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Shuang-xi Li

Associate Chief Surgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jiafu Ji, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Peking University Cancer Hospital & Institute

Locations

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Peking University Cancer Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shuangxi Li, M.D., Ph.D.

Role: CONTACT

Facility Contacts

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Shuangxi Li, M.D.

Role: primary

Other Identifiers

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INdex

Identifier Type: -

Identifier Source: org_study_id

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