Quality of Life in Patients With Rectal Cancer Receiving Total Mesorectal Excision With or Without Stoma

NCT ID: NCT03487484

Last Updated: 2020-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-22

Study Completion Date

2020-03-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal is to evaluate whether the renunciation of a diverting stoma in patients with adjuvant chemotherapy after low anterior resection with total mesorectal excision (TME) and neoadjuvant chemoradiotherapy leads to a better quality of life without increasing morbidity and mortality in patients with rectal cancer.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In most cases it is recommended that patients after low anterior resection with TME and neoadjuvant chemoradiotherapy for rectal cancer need a temporarily diverting stoma. Recent evidence suggests that this is not always necessary. The decision for or against a stoma is made by the surgeon in charge and is based on an algorithm of risk factors for anastomotic leakage. Many patients receive an adjuvant chemotherapy postoperative. This may influence the quality of life e.a. due to mucositis and urge incontinency or the stoma itself.The objective of this pilot study is to establish the basis for a randomized controlled trial. The long-term goal is to evaluate whether the renunciation of a diverting stoma in patients with adjuvant chemotherapy after low anterior resection with TME and neoadjuvant chemoradiotherapy leads to a better quality of life without increasing morbidity and mortality in patients with rectal cancer. All patients scheduled for low anterior resection of the rectum for rectal carcinoma will be invited to participate and prospectively enrolled into the study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Rectal Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

With protective stoma

Patients in which intraoperatively the decision was made to add a protective stoma (following a risk algorithm) to total mesorectal excision. In patients quality of life, the Gastrointestinal Quality of Life Index (GIQLI) questionnaire, Quality of Life Questionnaire for gastrointestinal tract and Faecal Incontinence Score will be applied.

Quality of Life Questionnaire for gastrointestinal tract

Intervention Type BEHAVIORAL

To assess quality of life, the GIQLI questionnaire (Gastrointestinal Quality of Life Index) will be applied

Quality of Life Questionnaire

Intervention Type BEHAVIORAL

To assess quality of life, the SF-36 questionnaire will be applied

Faecal Incontinence Score

Intervention Type BEHAVIORAL

To assess faecal incontinence, the Vaizey Wexner questionnaire will be applied

No stoma

Patients in which intraoperatively the decision was made to refrain from adding a protective stoma (following a risk algorithm) to total mesorectal excision.

In patients quality of life, the GIQLI questionnaire (Gastrointestinal Quality of Life Index), Quality of Life Questionnaire for gastrointestinal tract and Faecal Incontinence Score will be applied.

Quality of Life Questionnaire for gastrointestinal tract

Intervention Type BEHAVIORAL

To assess quality of life, the GIQLI questionnaire (Gastrointestinal Quality of Life Index) will be applied

Quality of Life Questionnaire

Intervention Type BEHAVIORAL

To assess quality of life, the SF-36 questionnaire will be applied

Faecal Incontinence Score

Intervention Type BEHAVIORAL

To assess faecal incontinence, the Vaizey Wexner questionnaire will be applied

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Quality of Life Questionnaire for gastrointestinal tract

To assess quality of life, the GIQLI questionnaire (Gastrointestinal Quality of Life Index) will be applied

Intervention Type BEHAVIORAL

Quality of Life Questionnaire

To assess quality of life, the SF-36 questionnaire will be applied

Intervention Type BEHAVIORAL

Faecal Incontinence Score

To assess faecal incontinence, the Vaizey Wexner questionnaire will be applied

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

GIQLI questionnaire SF-36 questionnaire Vaizey Wexner questionnaire

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age older than 18,
* low anterior resection and TME due to rectum carcinoma after standardized neoadjuvant combined chemo- and radiotherapy and receiving adjuvant postoperative chemotherapy,
* German speaking patient who is capable to fill in the questionnaire,
* signed informed consent

Exclusion Criteria

* age younger than 18,
* preoperative stoma,
* not German speaking
* inability to fill in the questionnaire,
* no standardized chemo- and radiotherapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Susanne Drews, MD

Role: PRINCIPAL_INVESTIGATOR

Claraspital Basel

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

St Claraspital

Basel, , Switzerland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Switzerland

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

QoL Rectal Cancer

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.