Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis
NCT ID: NCT03484091
Last Updated: 2025-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
276 participants
INTERVENTIONAL
2018-04-01
2023-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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H group
Single dose of Hyruan-One 3 mL intra-articular knee injection.
Hyruan-One
single dose intra-articular injection
S group
Single dose of Hylan G-F 20 (Synvisc) 6 mL intra-articular knee injection.
Hylan G-F 20
single dose intra-articular injection
N group
Single dose of normal saline 6 mL intra-articular knee injection.
Normal saline
single dose intra-articular injection
Interventions
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Hyruan-One
single dose intra-articular injection
Hylan G-F 20
single dose intra-articular injection
Normal saline
single dose intra-articular injection
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Gave informed consent
* Can do questionnaires
Exclusion Criteria
* Allergy to hyaluronic acid
* Pain in the hip or ankle
* Post-traumatic or post surgery of lower extremity
* Post-infection of the knee
* Previous hyaluronic acid injection within 6 months
* Pregnancy or lactation
* Underlying Rheumatoid arthritis, stroke, malignancy, venous occlusion
40 Years
80 Years
ALL
No
Sponsors
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Thammasat University
OTHER
Responsible Party
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Supakit Kanitnate
Department of orthopaedics
Principal Investigators
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Nattapol Tammachote, MD
Role: PRINCIPAL_INVESTIGATOR
Thammasat University
Locations
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Thammasat University
Khlong Luang, Changwat Pathum Thani, Thailand
Countries
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Other Identifiers
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OrthoTU09
Identifier Type: -
Identifier Source: org_study_id
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