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Vegetable Signature From Human Metabolomics Responses

NCT ID: NCT03483558

Last Updated: 2018-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-11

Study Completion Date

2015-05-28

Brief Summary

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The purpose of this study is to perform dietary intervention studies on a variety of vegetables.

Detailed Description

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Plant-based foods have always been an important component of a healthy diet. High intake of plant foods may not only maintain normal bodily functions through the provision of dietary fiber, vitamins, and minerals but also relieve symptoms and prevent diseases. Many studies have pointed out that high intake of plant foods may reduce the incidence of non-communicable disease. Past research investigating the effect of phytochemicals has usually been limited to single substances or single foods. However, a number of researchers have pointed out that phytonutrients and dietary components are likely to act synergistically.Health effects and mechanisms of phytonutrients in combination have not been carefully studied in population settings. The technology of metabolomics has enabled the simultaneous measurement of hundreds of small molecules in biological samples. Exploring the change of metabolites after feeding can not only help us understand the role of plant foods, but may also provide opportunities to assess plant food intake levels.

Conditions

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Vegetable Signature Documentation With Metabolomic Technique

Keywords

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vegetable metabolite signature human serum/urinary metabolite liquid chromatography mass spectrometry

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Control

Participants were fed a standardized diet (without any vegetables) in this experiment.

Group Type EXPERIMENTAL

Control

Intervention Type OTHER

A standardized diet without any vegetables was provided.

Spinach

Participants were fed a standardized diet with 200g spinach in this experiment.

Group Type EXPERIMENTAL

Spinach

Intervention Type OTHER

A standardized diet with 200g spinach was provided.

Celery

Participants were fed a standardized diet with 200g celery in this experiment.

Group Type EXPERIMENTAL

Celery

Intervention Type OTHER

A standardized diet with 200g celery was provided.

Onion

Participants were fed a standardized diet with 200g onion in this experiment.

Group Type EXPERIMENTAL

Onion

Intervention Type OTHER

A standardized diet with 200g onion was provided.

Mixed Vegetables

Participants were fed a standardized diet with 200g of mixed vegetables (spinach, celery, and onion) in this experiment.

Group Type EXPERIMENTAL

Mixed Vegetables

Intervention Type OTHER

A standardized diet with 200g of mixed vegetables (spinach, celery, and onion) was provided.

Interventions

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Control

A standardized diet without any vegetables was provided.

Intervention Type OTHER

Spinach

A standardized diet with 200g spinach was provided.

Intervention Type OTHER

Celery

A standardized diet with 200g celery was provided.

Intervention Type OTHER

Onion

A standardized diet with 200g onion was provided.

Intervention Type OTHER

Mixed Vegetables

A standardized diet with 200g of mixed vegetables (spinach, celery, and onion) was provided.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 18.5\~30 kg/m2
* non-smoker
* non-alcoholic

Exclusion Criteria

* Unwilling to stop taking the dietary supplements that may affect the experiment result.
* Unwilling to take the provided meal during the designated period.
* Taking hypertension or diabetes drugs.
* Diagnosed immune diseases (such as allergic diseases, autoimmune diseases, etc.), liver diseases, metabolic diseases (such as hyperthyroidism or hypothyroidism), or other not suitable for the dietary study.
* Diagnosed cancer or other severe diseases.
* Suffered from urinary tract infection or took antibiotic in the past three months
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Academia Sinica, Taiwan

OTHER

Sponsor Role collaborator

Tri-Service General Hospital

OTHER

Sponsor Role collaborator

Fu Jen Catholic University

OTHER

Sponsor Role collaborator

National Health Research Institutes, Taiwan

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wen-Harn Pan, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

National Health Research Institutes, Taiwan

Other Identifiers

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NHRI_EC0991003

Identifier Type: -

Identifier Source: org_study_id