Use of Human Dehydrated Amnion Chorion Allograft in Closed Hemorroidectomy

NCT ID: NCT03479489

Last Updated: 2019-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-05

Study Completion Date

2018-12-30

Brief Summary

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The purpose of this study is to determine the safety and effectiveness of human dehydrated amnion chorion allograft in closed hemorrhoidectomy as assessed by patient and wound assessments.

Detailed Description

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Conditions

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External Hemorrhoid External Hemorrhoid Thrombosed

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Human dehydrated amnion/chorion allofraft

Closed hemorrhoidectomy patched with human dehydrated amnion chorion allograft

Group Type EXPERIMENTAL

Human dehydrated amnion chorion allograft

Intervention Type OTHER

Closed hemorrhoidectomy patched with dehydrated human amnion chorion allograft

Interventions

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Human dehydrated amnion chorion allograft

Closed hemorrhoidectomy patched with dehydrated human amnion chorion allograft

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Confirmed diagnosis of acutely thrombosed hemorrhoid or an external hemorrhoid exceeding 72 hours in duration
2. Subject is undergoing closed hemorrhoidectomy as their definitive treatment for the Grade 2-4 hemorrhoid
3. Subject is age 18 or older
4. Subject is willing and able to provide informed consent and participate in all procedures and follow-up evaluations necessary to complete the study

Exclusion Criteria

1. Subject has a known history of poor compliance with medical treatments
2. Subject has signs and symptoms of active cirrhosis
3. Subject has signs and symptoms of Crohn's disease complicated by perianal manifestations
4. Subject is currently taking immunosuppressive medications
5. Subject has had previous surgery in the target area within the past 6 months prior to treatment or plans to have surgery other than closed hemorrhoidectomy in the target area within 180 days of treatment
6. Subject is currently receiving radiation therapy or chemotherapy
7. Subject has used an investigational drug, device or biologic within 12 weeks prior to treatment
8. Subject is pregnant at enrollment or is planning to become pregnant within 180 days of treatment; subject intends to breastfeed during the course of the trial
9. Subject has any significant medical condition(s) that, in the opinion of the Investigator, would interfere with protocol evaluation and participation
10. Subject has an allergy or known sensitivity to aminoglycoside antibiotics such as gentamicin sulfate and/or streptomycin sulfate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MiMedx Group, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Donald Fetterolf, MD

Role: STUDY_DIRECTOR

MiMedx Group, Inc.

Locations

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Boulder Valley Surgical Associates

Boulder, Colorado, United States

Site Status

Countries

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United States

Other Identifiers

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EFSUR001

Identifier Type: -

Identifier Source: org_study_id