Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy

NCT ID: NCT03479463

Last Updated: 2020-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-19

Study Completion Date

2019-03-30

Brief Summary

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This trial aims to determine if intra-operative use of human dehydrated amnion chorion allograft improves post-operative patient healing outcomes.

Detailed Description

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This study is to determine if intra-operative use of Amnio-Fix improves post-operative patient healing outcomes after laryngectomy and/or pharyngectomy.

Conditions

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Larynx Cancer Pharynx Cancer Pharyngocutaneous Fistula

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Treatment with Dehydrated Human Amnion Chorion Allograft

Dehydrated human amnion/chorion membrane

Intervention Type BIOLOGICAL

Laryngectomy/pharyngectomy patched with dehydrated human amnion chorion allograft

Standard of Care

No interventions assigned to this group

Interventions

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Dehydrated human amnion/chorion membrane

Laryngectomy/pharyngectomy patched with dehydrated human amnion chorion allograft

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

1. Subject is scheduled to undergo laryngectomy and/or pharyngectomy procedure due to oncological indication
2. Subject is age 18 or older
3. Subject is willing and able to provide informed consent and participate in all procedures and follow-up evaluations necessary to complete the study

Exclusion Criteria

1. Subjects currently enrolled in or planning to enroll in another clinical trial
2. Subjects with a known history of poor compliance with medical treatments
3. Subjects that are using or have used an investigational drug, device, or biologic within the 12 weeks prior to treatment
4. Subjects that have any significant medical condition(s) that, in the opinion of the Investigator, would interfere with protocol evaluation and participation
5. Subject has undergone previous pharyngeal reconstructive surgery
6. Pregnancy at enrollment or within last 6 months, women who are breastfeeding, or women of childbearing potential who are planning to become pregnant during the time of the study OR are unwilling/unable to use acceptable methods of contraception (birth control pills, barriers, or abstinence)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MiMedx Group, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Brett Miles, MD

Role: PRINCIPAL_INVESTIGATOR

MOUNT SINAI HOSPITAL

Locations

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Mount Sinai Hospital

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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AFSUR003

Identifier Type: -

Identifier Source: org_study_id