The Criteria for Lymph Node Sorting for Pathological Examination in Gastric Cancer

NCT ID: NCT03478449

Last Updated: 2020-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

276 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-01

Study Completion Date

2020-12-30

Brief Summary

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The aim of this study is intending to provide the optimal procedures of lymph node sorting for pathological examination after curative surgery for gastric cancer, which can discriminate the differences of the status of lymph node metastasis, pTNM classification and prognostic outcome of gastric cancer patients.

Detailed Description

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Conditions

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Lymph Node Metastases Gastric Cancer Exanimation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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Fine sorting lymph node group

Group Type EXPERIMENTAL

lymph node sorting for pathological examination

Intervention Type PROCEDURE

In this study, intervention methods include two kinds of lymph node sorting for pathological examination in gastric cancer samples after curative surgery. One is the fine sorting lymph nodes, representing the lymph nodes should be sorted one by one from the tissues around the stomach, celiac axis, and the main brunches of celiac axis. The other is the group sorting lymph nodes, representing the lymph nodes should be simply sorted in the soft tissues around the stomach, celiac axis, and the main brunches of celiac axis.

Regional sorting lymph node group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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lymph node sorting for pathological examination

In this study, intervention methods include two kinds of lymph node sorting for pathological examination in gastric cancer samples after curative surgery. One is the fine sorting lymph nodes, representing the lymph nodes should be sorted one by one from the tissues around the stomach, celiac axis, and the main brunches of celiac axis. The other is the group sorting lymph nodes, representing the lymph nodes should be simply sorted in the soft tissues around the stomach, celiac axis, and the main brunches of celiac axis.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 1\) Physical conditions compliance with the requirements for curative gastrectomy
* 2\) Consent to undergo the D2 lymphadenectomy
* 3\) Comply with the protocol during the whole study period
* 4\) No neoadjuvant therapy administration
* 5\) Sign informed consent and permission of withdraw in the whole study period
* 6\) Consent to provide the tissue specimens after surgery for this study
* 7\) Pathological examination confirmation the adenocarcinoma of stomach before surgery
* 8\) Estimation the overall survival after surgery no less than 6 months
* 9\) No anesthesia or operation contraindication disease
* 10\) cTanyNanyM0 stage demonstration by CT and endoscopic ultrasonography examinations
* 11\) Negative cytological detection in operation
* 12\) No seriously concomitance's diseases
* 13\) Karnofsky Performance Scores (KPS) more than 60

Exclusion Criteria

* 1\) Women during pregnant stage and breast-feed stage
* 2\) Women of childbearing age without any contraceptive measures
* 3\) Severe congestive heart failure, frequent arrhythmia, or myocardial infarction within 12 months
* 4\) Immunosuppressive therapists for organ transplantation
* 5\) Seriously uncontrolled recurrent infection
* 6\) other malignant tumors
* 7\) No abilities of self-knowledge or mental disorders
* 8\) Participating in other clinical trials
* 9\) Siewert I and II esophagogastric junction tumors
* 10\) Serious internal diseases obstruction surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cancer Hospital of Tianjin Medical University

Tianjin, , China

Site Status

Countries

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China

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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DJY001

Identifier Type: -

Identifier Source: org_study_id