Personalized Radiation Therapy for GBM

NCT ID: NCT03477513

Last Updated: 2025-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-01

Study Completion Date

2026-07-30

Brief Summary

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The study is a pilot study to estimate the efficacy of personalized dose-escalation radiation therapy in patients with glioblastoma, as measured by estimating the median of progression-free survival. Toxicity, patterns of recurrence, and overall median survival will be measured as secondary endpoints. Adverse events will be monitored.

Detailed Description

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Conditions

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Glioblastoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Single Arm

Dose-escalated radiation therapy

Group Type EXPERIMENTAL

Radation Therapy

Intervention Type RADIATION

Personalized Radiation Therapy

Interventions

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Radation Therapy

Personalized Radiation Therapy

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Patients with biopsy-proven WHO Grade IV glioblastoma, after gross-total or near-total resection, who are undergoing definitive chemoradiation as part of their treatment regimen
* Age 18 or older
* Ability to give signed informed consent
* Karnofsky Performance Status (KPS) at least 70

Exclusion Criteria

* Placement of Gliadel wafers
* Participation in another investigational trial
* Active treatment of another malignancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abramson Cancer Center at Penn Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michelle Alonso-Basanta, MD

Role: PRINCIPAL_INVESTIGATOR

Abramson Cancer Center at Penn Medicine

Locations

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Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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UPCC 24317

Identifier Type: -

Identifier Source: org_study_id

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