Laparoscopic Tubal Adhesiolysis Versus IVF-ICSI

NCT ID: NCT03476759

Last Updated: 2021-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2021-10-31

Brief Summary

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2groups with peritoneal adhesions after cesarean delivery will be allocated to either laparoscopic tubal adhesiolysis or to IVF/ICSI

Detailed Description

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This randomized clinical trial will be conducted at Tanta university hospitals in fertility and MIS units. Two hundred and fifty 2ry infertility patients with confirmed post C.S adhesions will be included in the study and those patients will be divided randomly in two groups:

Group A:

125 patients will be undergoing laparoscopic tubal adhesiolysis and\\or tuboplasty then a widow of 12 months post operatively is given for natural conception.

Group B:

125 patients will undergo IVF-ICSI procedures. The primary outcome measure of the study will be the rate of clinical pregnancy.

Inclusion criteria:

* patient's age not exceeding 35 years old
* confirmed post caesarean section tubal adhesions (by diagnostic laparoscopy report or video CDs) as a solitary cause of their 2ry infertility.

Exclusion criteria:

* patient's age \>35 years
* other causes of infertility as male factor contribution, any ovulatory or endocrinological disorder,
* diagnosed any degree of endometriosis
* patients with history of recurrent pregnancy loss.
* couples with prolonged sexual abstinence for any reason Detailed explanation of the aims, procedures, steps and nature of the study for the participants will be done and a written consent will be signed by each patient before inclusion.

After allocation laparoscopic tubal adhesions will be dissected and normal anatomy and function will be restored. In the other group IVF/ICSI will be commenced The follow up with both groups will extend to 1year or till pregnancy is aggrieved The outcomes of the study were pregnancy rates and affordability

Conditions

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Tubal Factor Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Tubal adhesiolysis

laparoscopic tubal adhesiolysis and\\or tuboplasty

Group Type ACTIVE_COMPARATOR

Tubal adhesiolysis

Intervention Type PROCEDURE

125 patients will undergo tubal adhesiolysis or tuboplasty

IVF/ICSI

These patients will undergo IVF/ICSI

Group Type ACTIVE_COMPARATOR

IVF/ICSI

Intervention Type DRUG

125 patients will undergo IVF-ICSI procedures.

Interventions

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Tubal adhesiolysis

125 patients will undergo tubal adhesiolysis or tuboplasty

Intervention Type PROCEDURE

IVF/ICSI

125 patients will undergo IVF-ICSI procedures.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age not exceeding 35 years old with confirmed post caesarean section tubal adhesions (by diagnostic laparoscopy report or video CDs) as a solitary cause of their 2ry infertility.

Exclusion Criteria

* patient's age \>35 years, male factor contribution, any ovulatory or endocrinological disorder, diagnosed any degree of endometriosis and patients with history of recurrent pregnancy loss. Couples with prolonged sexual abstinence for any reason will be excluded from participation in the study.
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Ayman S Dawood, MD

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ayman Dawood, MD

Role: PRINCIPAL_INVESTIGATOR

Lecturer at Tanta University

Locations

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Ayman Shehata Dawood

Tanta, Algharbia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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Tanta University

Identifier Type: -

Identifier Source: org_study_id