Phase I Trial of CArbonic Anhydrase Inhibition in Combination With Radiochemotherapy or Radioimmunotherapy in Small Cell Lung Carcinoma

NCT ID: NCT03467360

Last Updated: 2026-01-20

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-08-02
• Study Completion Date: 2027-04-27

Brief Summary

The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy or radioimmunotherapy in small cell lung cancer due to:

1. The over-expression of carbonic anhydrases in this type of cancer,

2. The Anti-tumor effect in preclinical acetazolamide in various tumor lines including neuroendocrine tumor lines,

3. The observed synergy between irradiation and inhibition of carbonic anhydrases,

4. Potential anti-tumor immune effect caused by decreased extracellular acidity.

Detailed Description

Compared with healthy cells, glucose metabolism is greatly modified in cancer cells because of their highly proliferative character. This differential tumor / healthy tissue property is an opportunity to be able to propose a treatment whose therapeutic gain can be major (targeted treatment). Preclinical studies are multiple and showed that the targeting of overexpressed proteins (carbonic anhydrases) and involved in glycolytic metabolism can lead to a significant anti-tumor effect. This has never been tested in humans.

Acetazolamide is a molecule commonly used for non carcinologic purposes but has demonstrated anti-tumor activity in preclinical studies; there is also synergy radiotherapy / targeting of carbonic anhydrases. Therefore, the investigators propose to study the combination of acetazolamide / radiotherapy / chemotherapy with platinum and etoposide in localized Small Cell Lung cancer, or associated with radioimmunotherapy (extensive SCLC).

This would be the first study:

• targeting glucose metabolism,
• testing the effectiveness of acetazolamide in oncology,
• testing the synergy radiotherapy / targeting glycolytic metabolism,
• trying to manipulate the anti-tumor immune system indirectly, by decreasing extracellular acidosis.

Conditions

Small Cell Lung Cancer

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Localized SCLC

non randomized, open-label extension cohort, evaluating the safety of acetazolamide in combination with platinum and etoposide-based radiochemotherapy in patients with Localized small lung cancer

Group Type: EXPERIMENTAL

acetazolamide in combination with platinum and etoposide-based radiochemotherapy

Intervention Type: DRUG

Radiation therapy will be combined with platinum and etoposide-based chemotherapy combined with 3-6 tablets per day of acetazolamide during the entire course of therapy (dosage appropriate to the inclusion phase).

Extensive SCLC

non randomized, open-label extension cohort, evaluating the safety of acetazolamide in combination with radioimmunotherapy in patients with extensive small cell lung cancer

Group Type: OTHER

acetazolamide in combination with radioimmunotherapy in patients with extensive SCLC

Intervention Type: DRUG

acetazolamide in combination with radioimmunotherapy in patients with extensive SCLC

Interventions

acetazolamide in combination with platinum and etoposide-based radiochemotherapy

Radiation therapy will be combined with platinum and etoposide-based chemotherapy combined with 3-6 tablets per day of acetazolamide during the entire course of therapy (dosage appropriate to the inclusion phase).

Intervention Type: DRUG

acetazolamide in combination with radioimmunotherapy in patients with extensive SCLC

acetazolamide in combination with radioimmunotherapy in patients with extensive SCLC

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age > or = 18 years,
• Performance Status 0 to 2,
• Patient with an histologically non-metastatic localized (or extensive SCLC sub-group) Small cell lung cancer,
• Patient who must start radiotherapy treatment combined with chemotherapy with platinum and etoposide (localized SCLC sub-group) or Patient who received 4 cycles of chemoimmunotherapy with platinum salts, etoposide and immunotherapy (atezolizumab or durvalumab) as the first treatment (extensive SCLC sub-group) Note: The decision of the Multidisciplinary Consultation Team must be notified in the patient's medical file,
• Evaluation lesion according to the criteria RECIST 1.1 and / or according to the criteria PERCIST 1.0,
• Women of childbearing potential must have a negative serum pregnancy test within 72 hours of the first administration of the study treatment,
• If the patient is a woman of childbearing potential, she must be surgically sterile or agree to use two adequate methods of contraception throughout the duration of the study until 1 month after the last administration of the study treatment. Subjects of childbearing potential are those who have not been surgically sterilized or have not been free from menses for > 1 year, Note: Abstinence is acceptable if it is the patient's usual and preferred form of contraception,
• If the male patient has one or more female partners of childbearing age, he / she must agree to use an adequate method of contraception, starting at the first administration of the study treatment up to 1 month after the last administration of the treatment. of the study, Note: Abstinence is acceptable if it is the patient's usual and preferred form of contraception,
• Patient willing and able to provide written informed consent/assent for the trial,
• Patient affiliated with a health insurance system.

Exclusion Criteria

• Patient with metastatic disease,
• History of thoracic irradiation or near / in the thoracic irradiation field,
• Patient who refuses to participate in the study or unable to agree,
• Contraindication to thoracic radiotherapy treatment: congestive heart failure unbalanced (ejection fraction <30%, clinical signs), severe respiratory failure:

• COPD grade IV according to the GOLD classification,
• Some GOLD III COPD and any patient with a respiratory defect defined as: oxygen dependence and / or FEV1 <40% normal and / or, DLCO <40% predictive value and / or vital capacity <40% predictive value,
• Contraindication to acetazolamide: hypersensitivity to acetazolamide, severe hepatic, renal or adrenal insufficiency, sulfonamide intolerance, history of renal colic, allergy to wheat other than celiac disease,
• Patient currently receiving one or more treatments described in section 6.9 of the protocol,
• History of cancer, with the exception of cancers in complete remission for more than 5 years, completely resected basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer,
• People particularly vulnerable as defined in Articles L.1121-5 to -8 of the French Healthcare Code, including: person deprived of freedom by an administrative or judicial decision, adult being the object of a legal protection measure or outside a state to express their consent, pregnant or breastfeeding women

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Antoine Lacassagne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Vanessa VIDAL

Role: STUDY_DIRECTOR

Centre Antoine Lacassagne

Locations

Centre Antoine Lacassagne

Nice, , France

Site Status: RECRUITING

Centre Hospitalier Princesse grace

Monte Carlo, , Monaco

Site Status: TERMINATED

Countries

France; Monaco

Central Contacts

Jérôme DOYEN, PH

Role: CONTACT

jerome.doyen@nice.unicancer.fr

+33492031270

Facility Contacts

Jérôme Doyen, MD

Role: primary

jerome.doyen@nice.unicancer.fr

+33492031270

Other Identifiers

2022-503093-36-00

Identifier Type: CTIS

Identifier Source: secondary_id

2017-002160-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2017/14

Identifier Type: -

Identifier Source: org_study_id