Role of Interferon-λ and Vaccine Response

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-01

Study Completion Date

2017-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The following observational study will investigate whether the vaccine response (antibodies, T and B cells) after allogeneic stem cell transplantation is influenced by genetic polymorphisms in the interferon lambda signal.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Studies of the Immune Response to Vaccination After Hematopoietic Stem Cell Transplantation

NCT01581164

Hematopoietic Stem Cell Transplant

COMPLETED

Immune Response to Vaccinations in Hematopoietic Stem Cell Transplant Recipients

NCT03659773

Vaccination Hematopoietic Stem Cells

COMPLETED NA

Markers of Inflammation in Hematopoietic Stem Cell Transplant

NCT00579397

Acute Graft Versus Host Disease

COMPLETED

Role of Immune and Inflammatory Response in Recipients of Allogeneic Haematopoietic Stem Cell Transplantation (SCT) Affected by Severe COVID19

NCT04349540

COVID19

UNKNOWN

Prospective Phase II Study for Assessment of Regulatory Immune Cell Populations After Allogeneic HSCT

NCT00587574

Allogeneic Hematopoietic Cell Transplant Recipients

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The research project deals with one of the most important virological preventive measures after stem cell transplantation: vaccination against influenza viruses. Patients with allogeneic stem cell transplantation may experience serious complications of influenza and are at higher risk for inadequate response to the vaccine. The research project will make it possible, in a translational-medical orientation, to investigate the exact influence of genetic polymorphisms of the Interferon (IFN)-λ signalling cascade on the immune response after vaccination. This knowledge will make it possible to identify high-risk patients for a poor vaccination response before vaccination and to personalize the current vaccination strategy (intra-muscular injection), e.g. by subcutaneous vaccination, repeated administration of the vaccine or vaccine with adjuvants.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vaccine Response Impaired Allogeneic Stem Cell Transplantation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

influenza A/B vaccine

Regardless of the study enrollment, a two-time influenza vaccination at the start of the flu season is recommended every 4 weeks for all patients after stem cell transplantation. The vaccine is a trivalent inactivated non-adjuvanted influenza virus vaccine containing two influenza A viruses: pandemic H1N1, and H3N2, and an influenza B virus

Intervention Type BIOLOGICAL