SUPERa Stenting After SUBintimal Crossing of TASC C-D Femoro-popliteal Lesions in CLI Patients

NCT ID: NCT03452293

Last Updated: 2022-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

92 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-07

Study Completion Date

2022-03-28

Brief Summary

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The study will evaluate the safety and efficacy of subintimal Supera stenting in complex de novo or re-occlusive CTO (TASC C-D) lesions in patients with CLI. This study will be performed based on a rigorous sample size calculation, which will allow us to have the statistical power to validate our conclusions and therefore establish the generalizability of this strategy.

Detailed Description

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The present study is designed as a prospective, open label, observational study.

The study will collect information about the medical care patients receive during their planned procedure. No additional testing or procedures will be done.

Patients elected for endovascular revascularization with SuperSub strategy will be asked their written consent to the use of their personal data.

Revascularization will be performed as per standard procedure of the sites. After discharge all patients will attend clinic visits at 30 days (±14 days), 6 months (±30 days), 12 months (±30 days) and 24 months (±30 days). Angiographic follow-up will be performed only in symptomatic patients, as clinically indicated and with the aim for a new treatment.

Conditions

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PAD

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Stent Peripheral System

Peripheral PTA with Supera Stent implantation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients with CLI and TASC C-D Fem-Pop CTO's
* Age ≥18 years
* Patient has signed an approved consent form
* Patients without previous stenting of the Fem-Pop segment


* Patent and hemodynamically normal iliac and common femoral arteries.
* At least one patent and healthy tibial vessel runoff to the foot.
* Patient has documented TASC C or D Fem-Pop CTO's prior to the study procedure
* Rutherford Category 4, 5 or 6
* Subintimal crossing of the occluded Fem-Pop vessels
* Supera Stenting From healthy to healthy arterial segment.

Exclusion Criteria

* Patient unwilling or unlikely to comply with Follow-Up schedule
* Endoluminal crossing of the CTO
* Inability to stent from "healthy to healthy" arterial segments.
* Inability to re-enter within the pre-specified Ideal Landing Zone (IDL)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione Italiana Vascolare

OTHER

Sponsor Role collaborator

EndoCore Lab s.r.l.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maria Salomone, MD

Role: STUDY_DIRECTOR

EndoCore Lab

Mariano L Palena, MD

Role: STUDY_CHAIR

Casa di Cura Abano Terme

Larry J Diaz, MD,PhD

Role: STUDY_CHAIR

Metro Health Hospital

Locations

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Metro Health Hospital

Wyoming, Michigan, United States

Site Status

Instituto Medico CENICLAR, Unidad Sanatorio de la Mujer

Rosario, Santa Fe Province, Argentina

Site Status

Ospedale di Avezzano

Avezzano, AQ, Italy

Site Status

Clinica San Michele

Maddaloni, CE, Italy

Site Status

A.O.U. Policlinico Vittorio Emanuele

Catania, CT, Italy

Site Status

A.O. Cardinale Panico

Tricase, LE, Italy

Site Status

Casa di Cura Abano Terme

Abano Terme, Padova, Italy

Site Status

A.O.U. Santa Maria della Misericordia

Perugia, PG, Italy

Site Status

Policlinico Tor Vergata

Roma, RM, Italy

Site Status

A.O. San Giovanni Addolorata

Roma, RM, Italy

Site Status

A.O.U. di Sassari

Sassari, SS, Italy

Site Status

Ospedale San Antonio Abate

Erice, TP, Italy

Site Status

Azienda Ospedaliera Santa Maria di Terni

Terni, TR, Italy

Site Status

AORN Antonio Cardarelli

Napoli, , Italy

Site Status

London North West HealthCare NHS Trust

London, England, United Kingdom

Site Status

Countries

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United States Argentina Italy United Kingdom

Other Identifiers

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EndoCore01

Identifier Type: -

Identifier Source: org_study_id

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