Effects of Open Thoracic Paravertebral Block on Postoperative Analgesia
NCT ID: NCT03449563
Last Updated: 2018-02-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
90 participants
INTERVENTIONAL
2016-09-01
2017-12-28
Brief Summary
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Detailed Description
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Methods: A total of 90 patients with American Society of Anesthesiologists (ASA) scores of Ⅰ or Ⅱ, scheduled for open pulmonary lobectomy under propofol - remifentanil total intravenous anaesthesia, were randomly divided into 3 groups (n = 30 each) by using a random number table: PCIA group (group G), Ultrasound-guided TPVB combined with PCIA group (group U), and open TPVB combined with PCIA group (group E). In group G, patients were received PCIA after the surgery. In group U, TPVB was performed on the operated side under ultrasound guidance with 0.25% ropivacaine 30 ml combined with the PCIA after the surgery. In group E, the TPVB was performed under the direct vision with 0.25% ropivacaine 30 ml combined with the PCIA. The Visual Analogue Score (VAS) at rest and during coughing, the sensory nerve block segment, as well as the respiratory rate were measured and recorded at different time-points. Furthermore, the hemodynamic vital signs at different time - points, the number of successfully delivered doses 48 h after the surgery, as well as the incidence of postoperative complications were also recorded and analyzed.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Placebo group (group G)
placebo
In Group G,patients were just received Patient-controlled intravenous analgesia after the surgery.
Ultrasound-guided TPVB group (group U)
Ultrasound-guided TPVB
In Group U, thoracic paravertebral block was performed on the operated side under ultrasound guidance with 0.25% ropivacaine 30 ml,and the Patient-controlled intravenous analgesia was administer after the surgery.
open TPVB group(group E)
Open TPVB
In Group E,the thoracic paravertebral block was performed under the direct vision with 0.25% ropivacaine 30 ml,and the Patient-controlled intravenous analgesia was administer after the surgery.
Interventions
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Open TPVB
In Group E,the thoracic paravertebral block was performed under the direct vision with 0.25% ropivacaine 30 ml,and the Patient-controlled intravenous analgesia was administer after the surgery.
Ultrasound-guided TPVB
In Group U, thoracic paravertebral block was performed on the operated side under ultrasound guidance with 0.25% ropivacaine 30 ml,and the Patient-controlled intravenous analgesia was administer after the surgery.
placebo
In Group G,patients were just received Patient-controlled intravenous analgesia after the surgery.
Eligibility Criteria
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Inclusion Criteria
* aged 35 - 75 years old
* with body mass index of 20 - 25 kg／m2,
* scheduled for open pulmonary lobectomy under general anaesthesia at the First Affiliated Hospital of Kunming Medical University
Exclusion Criteria
* diabetes; pre-existing liver, lung or kidney dysfunction;
* bilateral surgery; take operations again within 48 h after the surgery;
* with serious pulmonary infection and coagulation dysfunction
35 Years
75 Years
ALL
No
Sponsors
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Kunming Medical University
OTHER
Responsible Party
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Wenya Bai
Resident dictor
Principal Investigators
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Guoliang Zhao
Role: PRINCIPAL_INVESTIGATOR
First Affiliated Hospital of Kunming Medical University
Other Identifiers
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Nerve block
Identifier Type: -
Identifier Source: org_study_id