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Th17 Inducing Cytokines Pregnancy and After Postpartum

NCT ID: NCT03449186

Last Updated: 2018-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

114 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-01

Study Completion Date

2018-01-31

Brief Summary

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The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

Detailed Description

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IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Conditions

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Pregnancy

Keywords

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periodontitis postpartum

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Pregnancy group

Women, who were in their second trimester (weeks 16-24) or third trimester (weeks 25-34)selected for the study. Saliva and GCF samples were collected and clinical periodontal measurements were made gently

Saliva collection

Intervention Type OTHER

GCF collection

Intervention Type OTHER

Postpartum group

Postpartum women 6 months after giving birth recalled. Saliva and GCF samples were collected and clinical periodontal measurements were made.

Saliva collection

Intervention Type OTHER

GCF collection

Intervention Type OTHER

Interventions

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Saliva collection

Intervention Type OTHER

GCF collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* women 2 and 3 trimester of their pregnancy

Exclusion Criteria

* any known systemic disease,
* periodontal treatment within the last six months,
* patients having less than 10 teeth,
* smokers,
* individuals with a BMI \> 30 kg/m2,
* gestational diabetes and preeclampsia during pregnancy.
Minimum Eligible Age

19 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Aydin Adnan Menderes University

OTHER

Sponsor Role lead

Responsible Party

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Veli Özgen Öztürk

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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BAP-2015

Identifier Type: -

Identifier Source: org_study_id