Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
54 participants
INTERVENTIONAL
2018-03-01
2018-12-12
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Alternate day fasting
Participants randomised to Alternate Day Fasting weight loss intervention. One day fasting of 25% total energy requirements alternated with one day ad libitum intake until study completion at \>/=5% weight loss which is an average of 12 weeks.
Alternate Day Fasting
25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks.
Continuous caloric restriction
Participants randomised to continuous caloric restriction weight loss intervention. Every day intake of 75% total energy requirements until study completion at \>/=5% weight loss which is an average of 12 weeks.
Continuous dietary restriction
25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks.
Interventions
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Alternate Day Fasting
25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks.
Continuous dietary restriction
25% daily energy requirements every other day until study completion at \>/=5% weight loss which is an average of 12 weeks.
Eligibility Criteria
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Inclusion Criteria
* BMI of 25.0 - 34.9 kg/m2
Exclusion Criteria
* Currently enrolled in a weight loss programme or following a specific diet plan.
* History of eating disorders including binge eating.
* Taking any medication or supplements known to affect appetite or weight within the past month and/or during the study
* Pregnant, planning to become pregnant or breastfeeding
* History of anaphylaxis to food
* Known food allergies or food intolerance
* Smokers and those who have recently ceased smoking (\< 6 months)
* BMI \< 24.9 kg/m2 or \> 35 kg/m2
* Volunteers having lost significant amount of weight in the previous 6 months (± 4kg)
* Volunteers who exercise \> 3 days per week or have significantly changed their physical activity patterns in the past 6 months or who intend to change them during the study
* Participants receiving systemic or local treatment likely to interfere with evaluation of the study parameters
* Participants who work in appetite or feeding related areas.
* Participants who do shift work
18 Years
55 Years
FEMALE
Yes
Sponsors
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University of Illinois at Chicago
OTHER
University of Leeds
OTHER
Responsible Party
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Dr Graham Finlayson
Chair in Psychobiology
Principal Investigators
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Kristine Beaulieu, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Leeds
Graham Finlayson, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Leeds
Locations
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University of Leeds
Leeds, West Yorkshire, United Kingdom
Countries
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References
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Beaulieu K, Casanova N, Oustric P, Turicchi J, Gibbons C, Hopkins M, Varady K, Blundell J, Finlayson G. Matched Weight Loss Through Intermittent or Continuous Energy Restriction Does Not Lead To Compensatory Increases in Appetite and Eating Behavior in a Randomized Controlled Trial in Women with Overweight and Obesity. J Nutr. 2020 Mar 1;150(3):623-633. doi: 10.1093/jn/nxz296.
Other Identifiers
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LDS-DIVA-2017
Identifier Type: -
Identifier Source: org_study_id