Phase I Drug-drug Interaction of Omega-3 and Atorvastatin

NCT ID: NCT03438955

Last Updated: 2018-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2018-08-31

Brief Summary

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This study evaluates the safety and pharmacokinetic drug-drug interactions of omega-3 and atorvastatin in healthy male volunteers. Half of the participants will receive omega-3 for 16 days to be steady state of omega-3 and followed by omega-3 and atorvastatin in combination for 7 days. The other half will receive Atorvastatin for 7 days to be steady state of Atorvastatin, and followed by Atorvastatin and Omega-3 in combination for 16 days.

Detailed Description

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Conditions

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Hyperlipidemia, Hypertriglyceridemia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Cohort A

Administration of omacor soft capsule 4000mg for 16 days, and followed by omacor soft capsule 4000mg and Pritor tablet 40mg in combination for 7 days.

Group Type EXPERIMENTAL

Omacor

Intervention Type DRUG

Omacor soft capsule 4000mg for 16days

Omacor + Pritor

Intervention Type DRUG

Omacor soft capsule 4000mg + Pritor tablet 40mg for 7days

Cohort B

Administration of Pritor tablet 40mg for 7 days, and followed by Pritor tablet 40mg and Omacor soft capsule 4000mg in combination for 16 days.

Group Type EXPERIMENTAL

Pritor

Intervention Type DRUG

Pritor tablet 40mg for 7days

Pritor + Omacor

Intervention Type DRUG

Pritor tablet 40mg + Omacor soft capsule 4000mg for 16dyas

Interventions

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Omacor

Omacor soft capsule 4000mg for 16days

Intervention Type DRUG

Pritor

Pritor tablet 40mg for 7days

Intervention Type DRUG

Omacor + Pritor

Omacor soft capsule 4000mg + Pritor tablet 40mg for 7days

Intervention Type DRUG

Pritor + Omacor

Pritor tablet 40mg + Omacor soft capsule 4000mg for 16dyas

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 50kg or less of body weight and body mass index of 18 \~ 30kg/m²
* No congenital or chronic disease requiring treatment, and no pathological symptoms or findings as a result of medical examination
* Eligible for the clinical trial as a result of a clinical laboratory test, 12-lead ECG, V/S test at the screening

Exclusion Criteria

\-
Minimum Eligible Age

19 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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DongKoo Bio & Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Min Kyu Park, MD

Role: PRINCIPAL_INVESTIGATOR

Dong-A National Univ. Hos.

Locations

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Dong-A National University Hospital

Busan, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Min Kyu Park, MD

Role: CONTACT

+82 51 240 5180

Facility Contacts

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Min Kyu Park

Role: primary

Other Identifiers

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17OA-15003

Identifier Type: -

Identifier Source: org_study_id

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