Coffee Consumption and NASH in the French Population.

NCT ID: NCT03432377

Last Updated: 2021-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

107 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-15

Study Completion Date

2020-11-17

Brief Summary

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The aim of our study is to evaluate the effect of coffee consumption on the risk of severe liver fibrosis in French patients with NASH.

Detailed Description

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Conditions

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Non Alcoholic Steatohepatitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

Any newly diagnosed case of NASH histologically proven graded according to SAF criteria

Or Metabolic syndrome defined by the IDF 2005 criteria:

* waist size\> 94cm (men) or\> 80cm (women)
* and the presence of at least two of the following criteria:

* blood pressure: Systolic ≥ 130mmHg OR diastolic ≥ 85 mmHg OR antihypertensive treatment
* Triglycerides ≥ 1.5g / L or lipid-lowering therapy
* HDL cholesterol \<0.4 g / L (men) or \<0.5 g / L (women) or lipid-lowering therapy
* fasting blood glucose:\> 1 g / L or type 2 diabetes AND Hepatic steatosis diagnosed on liver imaging And liver fibrosis (diagnosed with a FibroScan\> 6 KPa)

Exclusion Criteria

* Age \<18 years
* Viral hepatitis and other chronic liver diseases
* Alcohol consumption\> 20g / day for women, 30g / day for men
* Liver biopsy or FibroScan dating more than 6 months before inclusion.
* History of bariatric surgery
* Serious psychiatric pathology (psychosis, dementia, severe depression) and patients under legal protection (tutelage, guardianship)
* Solid cancer or progressive hematology or \<2 years (except basal cell carcinoma or localized squamous cell carcinoma)
* Severe and terminal chronic renal insufficiency (estimated GFR \<30mL / min)
* Recent myocardial infarction \<6 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Versailles Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dr Hugues Blondon

Head of Hepatogastroenterology Service

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hugues BLONDON, Department head

Role: PRINCIPAL_INVESTIGATOR

Versailles Hospital

Locations

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Centre Hospitalier de Béziers

Béziers, , France

Site Status

Centre hospitalier Métropole Savoie

Chambéry, , France

Site Status

Centre Hospitalier Sud Francilien

Corbeil-Essonnes, , France

Site Status

Groupe Hospitalier Public Sud Oise

Creil, , France

Site Status

Centre Hospitalier Intercommunal de Créteil

Créteil, , France

Site Status

Centre Hospitalier de Gonesse

Gonesse, , France

Site Status

Centre Hospitalier de Hyères

Hyères, , France

Site Status

Centre Hospitalier Départemental Vendée

La Roche-sur-Yon, , France

Site Status

Centre Hospitalier de Bretagne Sud

Lorient, , France

Site Status

Hôpital de Melun

Melun, , France

Site Status

Centre hospitalier Annecy Genevois

Metz-Tessy, , France

Site Status

Centre hospitalier Montelimar

Montélimar, , France

Site Status

Hôpital de Diaconesses

Paris, , France

Site Status

Centre Hospitalier de Perpignan

Perpignan, , France

Site Status

Centre Hospitalier de Saint Denis

Saint-Denis, , France

Site Status

Centre Hospitalier de Sens

Sens, , France

Site Status

Countries

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France

Other Identifiers

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2016-A01872-49

Identifier Type: REGISTRY

Identifier Source: secondary_id

P16/17_COCANASH

Identifier Type: -

Identifier Source: org_study_id

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NCT03819283 UNKNOWN NA