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Health Outcomes After Participating in Exercise (HOPE)

NCT ID: NCT03430115

Last Updated: 2021-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

588 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-20

Study Completion Date

2021-07-27

Brief Summary

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Aging is associated with significant declines in muscle mass, strength, and physical performance, all of which lead to disability, loss of independence, and adverse clinical outcomes. Obesity exacerbates these age-related declines in function and is associated with poorer clinical outcomes and quality of life. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. The overall goals of this study are to determine if the short-term functional benefits of intentional weight loss are sustained long-term, and to examine the long-term benefits and risks of weight loss.

Detailed Description

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Obesity exacerbates age-related declines in function and is associated with poorer clinical outcomes and quality of life. Although clinical trials conducted study teams show that diet-induced weight loss interventions in obese older adults, when combined with exercise, improve body composition and physical and metabolic function in the short-term, the overall safety and long-term benefits of intentional weight loss in older adults remain controversial. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. Because of these concerns, health care providers are reluctant to recommend weight loss in obese older adults. The goal is to determine whether weight loss-induced improvements in body composition and physical and metabolic function observed in short-term clinical trials persist over time is critical to inform geriatric obesity treatment.

Conditions

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Weight Loss Obesity Aging

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Weight loss plus exercise (WL+EX)

This group was randomized and previously assigned to weight loss plus exercise.

No interventions assigned to this group

Exercise alone (EX)

This group was randomized and previously assigned to exercise alone.

No interventions assigned to this group

Weight loss alone (WL)

This group was randomized and previously assigned to weight loss alone.

No interventions assigned to this group

Control

This group was randomized and previously assigned to control.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All former participants from the five intervention trials who respond to our recruitment strategies will be scheduled for clinic/home visits or a phone interview.

Exclusion Criteria

* None - all former participants from the five intervention trials are eligible
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Wake Forest University Health Sciences

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Denise Houston, PhD

Role: PRINCIPAL_INVESTIGATOR

Wake Forest University Health Sciences

Locations

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Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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1R01AG056418-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB00043576

Identifier Type: -

Identifier Source: org_study_id