Multicenter, Randomized, Controlled and Double-blind Study of Efficacy and Safety of Endoscopic Gastric Tubulization in Patients With Non-alcoholic Steatohepatitis (NASH-APOLLO).

NCT ID: NCT03426111

Last Updated: 2018-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-18

Study Completion Date

2020-12-31

Brief Summary

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Nonalcoholic steatohepatitis is a growing public health problem affecting over 5% of the population. These patients are at increased risk of cardiovascular and liver-related death and have higher rates of malignancy.

The currently standard of care is weight loss and physical exercise, with histological and analytical improvement in patients achieving a 5-10% reduction in body weight. However, less than 25% of the subjects achieve this goal. In obese patients , restrictive surgical treatments and gastric bypass have been successful in improving the metabolic syndrome, insulin resistance and liver histology.

Currently, less invasive and less costly endoscopic techniques are being developed. These techniques also achieve a gastric restriction with similar results than bariatric surgery. One of these is the OverStitch® system (Apollo Endosurgery, Austin, TX, USA). Our aim is to evaluate the efficacy and safety of this method in the improvement of liver histology in obese patients with nonalcoholic steatohepatitis.

Detailed Description

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Conditions

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Non-Alcoholic Fatty Liver Disease Obesity

Keywords

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Non-Alcoholic Fatty Liver Disease NASH Obesity Endoscopic gastric tubulization Non-alcoholic steatohepatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Multicenter, randomized,controlled and double-blind study with two parallel arms, placebo (normal endoscopy and lifestyle modification) or endoscopic gastric tubulization with OverStitch® system (Apollo Endosurgery, Austin, TX, USA) and lifestyle modification.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Diagnostic upper endoscopy plus lifestyle modification.

Group Type PLACEBO_COMPARATOR

Lifestyle modification

Intervention Type BEHAVIORAL

Hypocaloric diet and moderate physical exercise

Treatment

Endoscopic gastric tubulization with OverStitch® system (Apollo Endosurgery, Austin, TX, USA) plus lifestyle modification.

Group Type ACTIVE_COMPARATOR

Endoscopic Gastric Tubulization with OverStitch® system (Apollo Endosurgery, Austin, TX, USA)

Intervention Type DEVICE

This endoscopic technique is defined as a gastric restriction by means of sutures of the entire gastric wall, transmurally, in order to simulate a gastric sleeve, in the same way as sleeve gastrectomy surgery. Gastroplasty is performed using an endoscopic suture system (OverStitch, Apollo Endosurgery Inc., Austin, Texas, USA) inserted into a dual-channel endoscope (GIF-2T160, Olympus Medical Systems Corp., Tokyo, Japan).

Lifestyle modification

Intervention Type BEHAVIORAL

Hypocaloric diet and moderate physical exercise

Interventions

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Endoscopic Gastric Tubulization with OverStitch® system (Apollo Endosurgery, Austin, TX, USA)

This endoscopic technique is defined as a gastric restriction by means of sutures of the entire gastric wall, transmurally, in order to simulate a gastric sleeve, in the same way as sleeve gastrectomy surgery. Gastroplasty is performed using an endoscopic suture system (OverStitch, Apollo Endosurgery Inc., Austin, Texas, USA) inserted into a dual-channel endoscope (GIF-2T160, Olympus Medical Systems Corp., Tokyo, Japan).

Intervention Type DEVICE

Lifestyle modification

Hypocaloric diet and moderate physical exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Men or women aged between 18 and 75 years (inclusive) at the time of the first screening visit.
2. They must provide signed written informed consent and agree to comply the study protocol
3. Body mass index\> 30 kg / m².
4. Histological confirmation of steatohepatitis in a diagnostic liver biopsy (biopsy obtained in the 6 months prior to randomization or during the selection period) with at least a score of 1 in each component of the NAS score (steatosis with a score of 0 to 3, degeneration by ballooning with a score of 0 to 2 and lobular inflammation with a score of 0 to 3) and fibrosis of 0 to \<4, according to the staging system of CRN fibrosis on NASH.
5. NAS score ≥ 4.
6. For patients without fibrosis or with stage 1 fibrosis, the NAS score≥5 and one of the following conditions (metabolic syndrome (definition NCEP ATP III), DM type II, HOMA-IR\> 6).
7. The liver biopsy should have been done with a 16 G trucut needle and the minimum size should be 25 mm.

Exclusion Criteria

1. Known heart failure (Grade I to IV of the classification of the New York Heart Association).
2. History of effective bariatric surgery in the 5 years prior to selection.
3. Patients with a history of clinically significant acute cardiac event in the 6 months prior to selection, such as: acute cardiovascular event, cerebrovascular accident, transient ischemic attack, or coronary heart disease (angina pectoris, myocardial infarction, revascularization procedures).
4. Weight loss of more than 5% in the 6 months prior to randomization.
5. Liver cirrhosis.
6. Non-cirrhotic portal hypertension.
7. Recent or current background of significant consumption of alcoholic beverages (\<5 years). In the case of men, significant consumption is usually defined as more than 30 g of pure alcohol per day. In the case of women, it is usually defined as more than 20 g of pure alcohol per day.
8. Esophagogastric varices.
9. Hepatocellular carcinoma
10. Portal thrombosis.
11. Pregnancy.
12. Refusal to give informed consent.
13. Any medical condition that could reduce life expectancy to less than 2 years, including known cancers.
14. Signs of any other unstable or clinically significant immunological, endocrine, hematological, gastrointestinal, neurological, neoplastic or psychiatric disease without treatment.
15. Instability or mental incompetence, so that the validity of the informed consent or the ability to comply with the study are uncertain.

16. Antibodies positive for the human immunodeficiency virus.
17. Aspartate aminotransferase (AST) and / or ALT\> 10 x upper limit of normal (ULN).
18. Total bilirubin\> 25 μmol / l (1.5 mg / dl).
19. Standardized international index\> 1.4.
20. Platelet count \<100 000 / mm3.
21. Serum creatinine levels\> 135 μmol / l (\> 1.53 mg / dl) in men and\> 110 μmol / l (\> 1.24 mg / dl) in women.
22. Significant renal disease, including nephritic syndrome, chronic kidney disease (patients with markers of hepatic injury or estimated glomerular filtration rate \[eGFR\] of less than 60 ml / min / 1.73 m2). If an abnormal value is obtained at the first screening visit, the eGFR measurement may be repeated before randomization within the following time frame: minimum 4 weeks after the initial test and maximum 2 weeks before the expected randomization. An abnormal repeated eGFR (less than 60 ml / min / 1.73 m2) leads to exclusion from the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Universitario Ramon y Cajal

OTHER

Sponsor Role collaborator

Hospital Universitario Marqués de Valdecilla

OTHER

Sponsor Role collaborator

Hospitales Universitarios Virgen del Rocío

OTHER

Sponsor Role collaborator

Puerta de Hierro University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jose Luis Calleja

Professor and Head of Hepatology Unit of Puerta de Hierro University Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Jose Luis Calleja

Majadahonda, Madrid, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Jose Luis Calleja, Prof

Role: CONTACT

Phone: +34911916000

Email: [email protected]

Javier Abad, MD

Role: CONTACT

Phone: +34650814289

Email: [email protected]

Facility Contacts

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Jose Luis Calleja, Prof

Role: primary

Javier Abad, MD

Role: backup

References

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Reference Type DERIVED
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Other Identifiers

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PI17-00499

Identifier Type: -

Identifier Source: org_study_id