Personalized Dietary Program and Markers of Wellness

NCT ID: NCT03424395

Last Updated: 2019-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-28

Study Completion Date

2018-12-21

Brief Summary

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The objective of this study is to determine the impact of an integrated personalized dietary and wellness program which includes dietary advice, meals, and counseling on health and wellness.

Detailed Description

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The objective of this study is to determine the impact of an integrated personalized dietary and wellness program, which includes personalized dietary advice, meals, and behavior guidance, on markers of health and wellness, body composition, and psychosocial measures. Behavior questionnaires, motivational interviewing, psychosocial questionnaires, and participants' self-generated data on diet, preferences, activity, and sleep will be used in combination with anthropometric and biological data (fasted blood-based measures following an oral protein glucose lipid tolerance test \[liquid meal challenge test\], and selected single nucleotide polymorphisms) to create individualized, tailored dietary advice, meal and counseling plans.

Conditions

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Healthy Metabolism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single arm (open-label) containing three periods: (1) run-in (control), (2) personalized advice/counseling and meals, (3) personalized advice/counseling only.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Personalized dietary and wellness program

An integrated personalized nutrition program which includes a combination of dietary and wellness advice/counseling on wellness and meals, or dietary and wellness advice/counseling alone, each for 10 weeks.

Group Type OTHER

Personalized dietary and wellness program

Intervention Type OTHER

Single arm intervention containing three periods: (1) run-in (control), (2) personalized advice/counseling and meals, (3) personalized advice/counseling only

Interventions

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Personalized dietary and wellness program

Single arm intervention containing three periods: (1) run-in (control), (2) personalized advice/counseling and meals, (3) personalized advice/counseling only

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female, 30-65 years of age, inclusive.
* BMI 18.5-39.9 kilograms per meters squared.
* Willing to follow study program instructions, including consumption of meals on site (5 days/week; breakfast and lunch), consumption of all provided meals, use of a Fitbit®, self-administered capillary blood draws and dried blood spot collection, and visit schedule, where relevant.
* Willing and able to comply with the visit/contact schedule.
* Willing to avoid vigorous activity and alcohol consumption (24 h) and willing to fast (10-14 h, water only) prior to completion of the at-home oral protein glucose lipid tolerance test.
* Normally active and judged to be in good health on the basis of the medical history.
* Understands the study procedures and signs forms providing informed consent to participate in the study and authorization for release of relevant protected health information to the study Investigators.
* Subject has access to an internet-ready device and email.

Exclusion Criteria

* A history or presence of clinically important endocrine, cardiovascular, pulmonary, hepatic, renal, hematologic, immunologic, dermatologic, neurologic, psychiatric or biliary disorders that could interfere with the interpretation of the study results.
* A history or presence of a gastrointestinal condition that could potentially interfere with digestion and absorption of the study product including, inflammatory bowel disease, irritable bowel syndrome, chronic constipation, and history of frequent diarrhea; and gastroparesis.
* Uncontrolled hypertension (systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥100 mm Hg).
* A history or presence of cancer in the prior 2 years, except for non-melanoma skin cancer.
* A history of unconventional sleep patterns.
* Major trauma or a surgical event within 3 months of screening.
* Nicotine users.
* Use of medications which can alter the lipid profile with the exception of stable statin use.
* Unstable use of any thyroid medication.
* Use of antibiotics, hypoglycemic medications, and/or systemic corticosteroids.
* Signs or symptoms of an active infection.
* Current or recent history of drug or alcohol abuse.
* Known allergy and/or sensitivity to the study foods or products.
* Extreme dietary habits (e.g., very high protein diets, vegan, very low carbohydrate, etc.).
* A change (increase or decrease) in body weight of \>10%.
* Females who are pregnant, planning to be pregnant during the study period, lactating, or of childbearing potential and is unwilling to commit to the use of a medically approved form of contraception throughout the study period.
* Study staff or those who will be involved in the conduct of the study.
Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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TNO

OTHER

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role collaborator

Habit, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joshua C Anthony, PhD

Role: PRINCIPAL_INVESTIGATOR

Habit, LLC

Barbara L Winters, PhD, RD

Role: PRINCIPAL_INVESTIGATOR

Winters Nutrition Associates LLC

Kristin M Nieman, PhD

Role: STUDY_DIRECTOR

Katalyses LLC

Locations

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Campbell Soup Company

Camden, New Jersey, United States

Site Status

Countries

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United States

References

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Related Links

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http://doi.org/10.17226/10490

Institute of Medicine - Dietary Reference Intakes

http://www.who.int/dietphysicalactivity/physical_activity_intensity/en/

World Health Organization - Physical Activity Definitions

http://apps.who.int/iris/bitstream/10665/44583/1/9789241501491_eng.pdf

World Health Organization: Waist and Hip Circumference Ratio

Other Identifiers

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Habit-1701

Identifier Type: -

Identifier Source: org_study_id

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