Evaluation of ReX-C System in Measurement and Improvement of Patients' Adherence.

NCT ID: NCT03424330

Last Updated: 2023-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-09

Study Completion Date

2023-12-25

Brief Summary

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The study aims to evaluate the safety, usability and efficacy of the ReX-C - a novel medication management system - in measurement and improvement of adherence, in patients receiving oral anti-coagulation therapy for the treatment and prevention of thromboembolism.

Detailed Description

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ReX-C is a mobile system intended to provide solid, oral medication on patient demand, according to a pre-programmed treatment protocol. ReX-C addresses poor adherence to medication therapy by providing real-time, reliable adherence data to caregivers and timely, personalized reminders to patients.

During the study, the use of ReX-C system to receive medications will be compared to Standard of Care. Patients' adherence will be evaluated for both methods.

Conditions

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Thromboembolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

The study will employ a randomized, controlled crossover study design.

The study comprises two stages:

* Stage 1: ReX-C Intervention in which subjects will use ReX-C to receive medication.
* Stage 2: Control, in which Treatment as Usual (TAU). All subjects enrolled for the study will participate in both stages in a randomized crossover mode.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Arm1 - ReX first

Subjects begin with the ReX-C Intervention stage followed by Standard of Care stage.

Group Type EXPERIMENTAL

ReX-C intervention

Intervention Type DEVICE

Patients receive medication by the ReX-C device

Standard of Care

Intervention Type OTHER

Patients receive medication as usual

Arm 2- Standard of Care first

Subjects start with Standard of Care stage followed by ReX-C Intervention.

Group Type EXPERIMENTAL

ReX-C intervention

Intervention Type DEVICE

Patients receive medication by the ReX-C device

Standard of Care

Intervention Type OTHER

Patients receive medication as usual

Interventions

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ReX-C intervention

Patients receive medication by the ReX-C device

Intervention Type DEVICE

Standard of Care

Patients receive medication as usual

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Male or Female, at least 18 years of age
2. Subject is able to swallow pills and use ReX-C device to receive medication.
3. Subject is able to read and understand the Informed Consent Form.
4. Subject receives anti-coagulants for the treatment and prevention of thromboembolism events, (e.g: Arterial Fibrillation (AF), Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)).
5. Subject receives Novel Oral Anti-coagulant (NOAC); including; Pradaxa® (dabigatran), Xarelto® (rivaroxaban) and Eliquis® (apixaban).

1. Subject is recruited at least 1 month after treatment initiation and has stable dose regime.
2. Subject receives stable dose of medication for at least a month.
6. Subject takes medication therapy at home.

Exclusion Criteria

1. Subject has significant physical disability including; poor fine motor skills, impaired visual or auditory faculties, mental disorders or other impairment affecting ability to provide Informed Consent Form or use the ReX-C dispensing unit effectively.
2. Subject cen not use ReX-C to receive medications.
3. Subject is participating in another clinical study that does not permit participation in two studies simultaneously.
4. Subject is at end stage or terminal illness with anticipated life expectancy of 6 months or less.

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Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dosentrx Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Meir Preis, MD

Role: PRINCIPAL_INVESTIGATOR

Carmel Medical Center, Haifa, Israel

Locations

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Carmel Medical Center

Haifa, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Ronit Shtrichman, Ph.D

Role: CONTACT

Phone: 972526500938

Email: [email protected]

Hadas ONeill, BA

Role: CONTACT

Phone: +972503221947

Email: [email protected]

Facility Contacts

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Meir Preis, MD

Role: primary

Other Identifiers

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RXC-154-2017-CLE

Identifier Type: -

Identifier Source: org_study_id