A Study of ASN007 in Patients With Advanced Solid Tumors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

49 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-19

Study Completion Date

2020-06-30

Brief Summary

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The study is divided into two parts. The first part of the study will test various doses of ASN007 to find out the highest safe dose to test in five specific groups. The second part of the study will test how well ASN007 can control cancer.

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Detailed Description

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Part A is a dose escalation study to determine a safe and tolerable dose of ASN007 for patients with advanced solid tumors. Part A will also describe how the body works on ASN007(pharmacokinetics) and the effects of ASN007 on the body (pharmacodynamics) of ASN007, through blood sampling and optional biopsies..

Part B of the study will enroll patients with particular tumor types and genetic mutations for treatment at the Recommended Phase 2 Dose. Part B will enroll patients in five groups of fifteen patients each:

Group 1: Patients with metastatic BRAF mutated melanoma Group 2: Patients with metastatic NRAS and HRAS mutated solid tumors Group 3: Patients with metastatic KRAS mutated colorectal cancer (CRC) Group 4: Patients with metastatic KRAS mutated non-small cell lung cancer (NSCLC) Group 5: Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) Patients with melanoma will be required to have pre-dose and post-dose biopsies.

Group 6: Patients with metastatic MEK1, BRAF V600E, non-BRAF V600E solid tumors or BRAF fusions without prior treatment with BRAF, MEK, ERK inhibitors

Conditions

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Cancer Malignancy Neoplasia Neoplasm Neoplasm Metastasis Colon Cancer Colonic Neoplasms Colon Cancer Liver Metastasis Metastatic Cancer Metastatic Melanoma Metastatic Colon Cancer Metastatic Lung Cancer Non Small Cell Lung Cancer Metastatic Pancreatic Cancer Pancreas Cancer Pancreas Adenocarcinoma Pancreas Neoplasm Metastatic Nonsmall Cell Lung Cancer Metastatic Pancreatic Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ASN007: ascending doses

Oral drug for the treatment of advanced solid tumors

Intervention Type DRUG

ASN007 RD

Oral drug for the treatment of advanced solid tumors

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Written informed consent obtained prior to any study-related procedure being performed;
* Male or non-pregnant, non-lactating female patient at least 18 years of age at the time of consent;
* Eastern Cooperative Oncology Group Performance Status 0-1 (Part A) and PS 0-2 (Part B)
* Histologically or cytologically confirmed
* advanced or metastatic solid tumor (Part A)
* Group 1: BRAF mutant melanoma (Part B)
* Group 2: NRAS or HRAS mutant solid tumors(Part B)
* Group 3: KRAS mutant CRC.(Part B)
* Group 4: KRAS mutant NSCLC (Part B)
* Group 5: Pancreatic Ductal Adenocarcinoma (Part B)
* Progressive disease after failure of or intolerant to all available standard systemic treatments that have shown a documented benefit in overall survival for their respective tumor type.
* Measurable or evaluable disease per RECIST v1.1
* Screening hematology values of the following:
* absolute neutrophil count ≥ 1000/μL,
* platelets ≥ 100,000/μL,
* hemoglobin ≥ 9 g/dL
* Screening chemistry values of the following:
* alanine aminotransferase (ALT) and aspartate transaminase (AST) ≤ 3.0 × upper limit of the normal (ULN),
* total bilirubin ≤ 1.5 × ULN,
* creatinine ≤ 1.5 × ULN,,
* albumin ≥ 2.8 g/dL.
* Screening heart function lab test
* creatinine kinase - MB, troponin-I, and troponin-T within normal limits
* Subject is willing and able to comply with all protocol required visits and assessments, including biopsy if assigned.

Exclusion Criteria

* Prior treatment with ASN007 or another ERK1/2 inhibitor
* Known hypersensitivity to ASN007 or its excipients;
* Part B: Prior treatment with a RAF or MEK pathway inhibitor, except BRAFmutant melanoma (Group 1)
* Prior chemotherapy, targeted therapy or monoclonal antibody therapy within 3 weeks of start of study treatment (Day1), or 5 half-lives, whichever is shorter.
* Concurrent or prior bone marrow factors (e.g. G-CSF, GM-CSF or erythropoietin) within 3 weeks prior to Day 1 of treatment.
* Febrile neutropenia or serious persistent infection within 2 weeks prior to Day 1 of treatment
* Failure to recover from major surgery or traumatic injury within 4 weeks or minor surgery within 2 weeks prior to Day 1 of treatment.
* History of or current evidence / risk of retinal vein occlusion (RVO) central serous retinopathy (CSR), or glaucoma with intraocular pressures ≥ 21 mmHg or other pre-existing ocular conditions that may put the patient at risk for ocular toxicities
* Known central nervous system (CNS) primary tumor, CNS metastases or carcinomatous meningitis (Part A). Patients may be enrolled with CNS metastasis in certain circumstances in Part B.
* Clinically significant heart disorders including an ejection fraction of \< 50%
* Other serious uncontrolled conditions such as fungal, bacterial or viral infection; HIV, Hepatitis B or C, bleeding disorders, interstitial lung disease,
* Any other condition that might place the patient at undue risk.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No