Assessment of Change in Atherosclerotic Plaque by Serial CCTA

NCT ID: NCT03414840

Last Updated: 2018-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2020-10-31

Brief Summary

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Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.

Detailed Description

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Conditions

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Coronary Artery Disease Hydroxymethylglutaryl-CoA Reductase Inhibitors Coronary Arteriosclerosis

Keywords

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coronary artery disease coronary computed tomography angiography statins coronary atherosclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Atorvastatin

Patients diagnosed with coronary artery disease by CCTA be enrolled. Among enrolled patients, patients who is indicated to statin treatment according to the current ACC/AHA guideline will be treated with atorvastatin.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent clinically indicated CCTA (index CCTA)
* Mild to moderate stenosis (25-69%) on CCTA
* ≥1 clinical risk factors (Smoking, HTN, HDL\<40, Premature FHx, M ≥45, F ≥55) for CAD

Exclusion Criteria

* Acute coronary syndrome (unstable angina or MI)
* Positive (not equivocal) stress test
* Contraindications to statin
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chong Kun Dang Pharmaceutical Corp.

INDUSTRY

Sponsor Role collaborator

Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Hyuk-Jae Chang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hyuk-Jae Chang, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Yonsei University

Locations

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Severance Cardiovascular Hospital, Yonsei University College of Medicine

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Hyuk-Jae Chang, MD, PhD

Role: CONTACT

Phone: +82-2-2228-8454

Email: [email protected]

Sang-Eun Lee, MD, PhD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Hyuk-Jae Chang, MD, PhD

Role: primary

Other Identifiers

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2017-2669-001

Identifier Type: -

Identifier Source: org_study_id