Effects of Concord Grape Juice Alone on Glycemia, Appetite and Cognitive Function in Healthy Adults

NCT ID: NCT03409484

Last Updated: 2020-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-10

Study Completion Date

2019-09-20

Brief Summary

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Assess the impact of 100% grape juice on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

Detailed Description

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Investigators earlier clinical work and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on appetite and glycemia. Investigators aim to better understand the use of 100% grape juice modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

Conditions

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Glycemic Response Appetitive Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Concord Grape Juice

100% Concord Grape Juice

Group Type ACTIVE_COMPARATOR

Concord Grape Juice

Intervention Type OTHER

Concord Grape Juice

Low flavonoid low essence beverage

Low flavonoid low essence beverage

Group Type SHAM_COMPARATOR

Low flavoniod low essence beverage

Intervention Type OTHER

Low flavoniod low essence beverage

Low flavonoid beverage

Low flavonoid beverage

Group Type SHAM_COMPARATOR

Low flavonoid beverage

Intervention Type OTHER

Low flavonoid beverage

Interventions

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Concord Grape Juice

Concord Grape Juice

Intervention Type OTHER

Low flavoniod low essence beverage

Low flavoniod low essence beverage

Intervention Type OTHER

Low flavonoid beverage

Low flavonoid beverage

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI between 25.0-34.9 kg/m2
* Willingness to eat all test foods
* Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day.
* Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)

Exclusion Criteria

* Taking medications known to affect glycemia, lipid metabolism or appetite
* Body weight fluctuation of \>5kg in the past 3 months
* Taking vitamin or other supplements
* Smokers
* Acute or Chronic disease
Minimum Eligible Age

25 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Welch's Food Corporation

UNKNOWN

Sponsor Role collaborator

Purdue University

OTHER

Sponsor Role lead

Responsible Party

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Richard Mattes

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Richard D Mattes, PhD

Role: PRINCIPAL_INVESTIGATOR

Purdue University

Locations

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Purdue University

West Lafayette, Indiana, United States

Site Status

Countries

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United States

References

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Coelho OGL, Alfenas RCG, Debelo H, Wightman JD, Ferruzzi MG, Mattes RD. Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial. Food Funct. 2021 Nov 15;12(22):11469-11481. doi: 10.1039/d1fo02049h.

Reference Type DERIVED
PMID: 34698750 (View on PubMed)

Other Identifiers

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055-048

Identifier Type: -

Identifier Source: org_study_id