Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

230 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-12-20

Study Completion Date

2033-06-23

Brief Summary

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Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

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Detailed Description

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Conditions

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Intracranial Aneurysms Ruptured Aneurysm

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Collection of blood sample in aneurysm

In case of an endovascular treatment :

* A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure.
* Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

In case of a surgery treatment :

* A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery.
* A Tissue sample will be taken during the surgery
* Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient aged 18 and over
* Patient presenting a single or multiple aneurysm
* Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm