Trial Outcomes & Findings for Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy (NCT NCT03403361)

Last Updated: 2024-03-01

Results Overview

Recruitment status

TERMINATED

Study phase

Target enrollment

36 participants

Primary outcome timeframe

Day 1

Results posted on

2024-03-01

Participant milestones
Measure	Dual-Energy CT Scan Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
Overall Study STARTED	36
Overall Study COMPLETED	20
Overall Study NOT COMPLETED	16

Reasons for withdrawal
Measure	Dual-Energy CT Scan Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
Overall Study Not imaged due to issues during the pandemic	16

Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

Baseline characteristics by cohort
Measure	Dual-Energy CT Scan n=36 Participants Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
Age, Continuous	66.5 years n=5 Participants
Sex: Female, Male Female	15 Participants n=5 Participants
Sex: Female, Male Male	21 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	2 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	34 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	1 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	5 Participants n=5 Participants
Race (NIH/OMB) White	30 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants
Region of Enrollment United States	36 participants n=5 Participants

Timeframe: Day 1

Population: 16 participants did not have imaging due to staffing changes and lack of communication during the pandemic.

Outcome measures
Measure	Dual-Energy CT Scan n=20 Participants Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT Head and Neck Patients	0.9 percentage relative to prescribed dose Standard Deviation 1.8
Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT Lung Patients	1.0 percentage relative to prescribed dose Standard Deviation 2.8

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Adverse event data not reported

Adverse event data not reported

Washington University School of Medicine

Phone: 314-362-8567