Study of Apatinib Combined With TACE in Advance Hepatocellular Carcinoma

NCT ID: NCT03398122

Last Updated: 2018-01-12

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 248 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-11-14
• Study Completion Date: 2019-04-01

Brief Summary

the purpose of this study is to evaluate the efficacy and safety of aptinib in patients with advanced HCC

Detailed Description

HCC The is a common malignancy in the world, especially in China. Advanced HCC treatment is difficult and the prognosis is poor, which is still a great challenge and threat to the medical profession. The advent of the molecular targeted drug, Sola, has made the treatment dilemma of advanced HCC a breakthrough, but the efficacy and economic health ratio is far from satisfactory. After Sola, many new molecular targeted drugs were studied, but failed.

Although multiple treatment options, but for HCC Patient-recommended treatment programs require systematic treatment and surgery, TACE , local ablation and radiotherapy and other multidisciplinary means of combination, the selection of appropriate patients, appropriate means and timing to achieve individualized treatment.

1. Aptinib Union TACE can be generated through embolization and angiogenesis by the dual target of vascular suppression;2. TACE induces hypoxia, leading to an increase in the number of hypoxia-inducing factors that increases VEGF and PDGFR , while VEGF the and PDGFR may be important factors that induce tumor recurrence by stimulating tumor angiogenesis.

Conditions

Hepatocellular Carcinoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Apatinib combined with TACE

patients received Aptinib, 250 mg daily after TACE treatment, for 4-6 weeks

Group Type: EXPERIMENTAL

TACE

Intervention Type: PROCEDURE

epirubicin 30-60mg was injected into the blood supply artery of the tumor ,Embolization was subsequently performed with granules of gelatin sponge particles.

Apatinib

Intervention Type: DRUG

a molecular targeted anti-tumor drugs,small molecule vascular endothelial growth factor receptor 2 inhibitor

chemoemtranscatherer arterial bolization

epirubicin 30-60mg was injected into the blood supply artery of the tumor ,Embolization was subsequently performed with granules of gelatin sponge particles.

Group Type: PLACEBO_COMPARATOR

Apatinib

Intervention Type: DRUG

a molecular targeted anti-tumor drugs,small molecule vascular endothelial growth factor receptor 2 inhibitor

Interventions

TACE

epirubicin 30-60mg was injected into the blood supply artery of the tumor ,Embolization was subsequently performed with granules of gelatin sponge particles.

Intervention Type: PROCEDURE

Apatinib

a molecular targeted anti-tumor drugs,small molecule vascular endothelial growth factor receptor 2 inhibitor

Intervention Type: DRUG

Other Intervention Names

chemoemtranscatherer arterial bolization; ai tan

Eligibility Criteria

Inclusion Criteria

1. Age: 18-70 years old;

2. initial treatment diagnosed by histopathological or cytological examination BCLC Staging B/C Hepatocellular carcinoma of the liver ( HCC ) and at least one of the largest tumors in measurable lesions ≤15cm ;

3. Child-pugh liver function Rating: A level, B level;

4. BCLC Staging as B / C period;

5. before join in the group 1 weeks ECOG PS Rating: 0-1 score; estimated Lifetime ≥12 Week; Lab metrics meet the following criteria: ( 1 ) Blood routine check:

1. HB≥90 g/L;

2. ANC≥1.5x109/L;

3. PLT≥60x109/L; ( 2 ) Biochemical Examination:

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1. ALB≥29 g/L;

2. ALT and AST<2.5*ULN;

3. TBIL ≤ 2*ULN;

4. Cr ≤ 1.5*ULN;

6. women of childbearing age must be pregnancy tests before join in the group in 7 days;

7. Participants volunteered to join this study should sign informed consent, with good compliance and follow-up.

Exclusion Criteria

1. Central hepatic artery / hepatic venous fistula in patients with hepatocellular carcinoma, diffuse liver cancer patients, with large vascular invasion of liver cancer patients (including portal vein tumor thrombus);

2. hepatobiliary cell carcinoma and mixed cell carcinoma are known; previous ( 5 year) or at the same time suffering from other incurable malignancies, except for the cured basal cell carcinoma of the skin and cervical carcinoma in situ;

3. clinically symptomatic ascites that requires therapeutic celiac puncture or drainage with high blood pressure and cannot be reduced to normal range by anti hypertensive medications (systolic pressure > 140 mmHg , diastolic pressure >90 mmHg );

4. Suffering Ⅱ above-level myocardial ischemia or myocardial infarction, control of poor arrhythmia (including QTC inter-phase male ≥450 ms , female ≥470 ms );

5. Follow NYHA Standard Ⅲ ~ Ⅳ grade heart insufficiency or heart color Doppler ultrasonography: LVEF (left ventricular ejection fraction) < 50% ;

6. There are various factors affecting oral medication (e.g.inability to swallow, chronic diarrhea and intestinal obstruction, which significantly affect drug use and absorption);

7. previous within 6 months there is a history of gastrointestinal bleeding or a clear tendency to gastrointestinal bleeding, such as: bleeding risk of esophageal varices, local active ulcer lesions, fecal occult blood ≥ ( ++ ) not in group; fecal occult blood (+ ), requiring gastroscopy;

8. before participating in this study There were abdominal fistula, gastrointestinal perforation or celiac abscess in the day;

9. Coagulation dysfunction ( INR > 1.5 or prothrombin time ( PT ) > ULN+4 seconds), with bleeding tendencies or undergoing thrombolysis or anticoagulant therapy;

10. patients who have undergone central nervous system metastasis or known brain metastases;

11. patients with objective evidence of the history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, and severe lung impairment;

12. urine proteins are routinely shown ≥++ or confirmed 24 hour urine protein ration > 1.0 g ;

13. before participating in the study 7 days use strong-effect in CYP3A4 inhibitor therapy, or prior to participating in the study 12 days use the strong-effect in CYP3A4 inducer Therapy;

14. pregnant or lactating women who are not willing or unable to take effective contraceptive measures;

15. A history of mental illness, or psychotropic substance abuse;

16. Union HIV infected patients;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Zhi Guo, MD

Role: STUDY_CHAIR

Tianjin Medical University Cancer Institute and Hospital

Locations

Tianjin Medical University Cancer Hospital

Tianjin, Tianjin Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Zhi Guo, MD

Role: CONTACT

cjr.guozhi@vip.163.com

18622221211

Haipeng Yu, MD

Role: CONTACT

jieruke@yahoo.com.cn

13352070835

Facility Contacts

Zhi Guo, MD

Role: primary

cjr.guozhi@vip.163.com

13920076145

Haipeng Yu, MD

Role: backup

jieruke@yahoo.com.cn

13352070835

Other Identifiers

Ahead-HBH001

Identifier Type: -

Identifier Source: org_study_id