FreeDom: Innovative Strategy for the Management of COPD Exacerbations

NCT ID: NCT03396172

Last Updated: 2024-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-24

Study Completion Date

2025-12-31

Brief Summary

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The main objective of the study is to assess the "FreeDom" innovative strategy (FreeO2 at Domicile) to reduce hospitalization duration in patients with COPD exacerbation. This strategy associates early hospital discharge, automated O2 flow weaning with FreeO2 system, telemedicine and tele-rehabilitation.

The main hypothesis of this study is that the FreeDom strategy will reduce the number of hospitalization day by 50 percent at day 30.

Detailed Description

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The main objective of the study is to assess the "FreeDom" innovative strategy (FreeO2 at Domicile) to reduce hospitalization duration in patients with COPD exacerbation. This strategy will enable an early return home, patients using an innovative device that automatically adjusts and wean the oxygen flow (FreeO2 system) coupled to telemedicine and tele-rehabilitation.

The main hypothesis of this study is that a strategy for an early return home with a home hospitalization managed by telemedicine will reduce the length of hospitalization by 50 percent from 30 days.

Conditions

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Oxygen Deficiency COPD Exacerbation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

The intervention is an hospitalization with usual care. The hospitalization will take place in the usual setting and the hospital discharge will be decided by pulmonologists according to the usual criteria

Group Type OTHER

Control

Intervention Type OTHER

The hospitalization will take place in the usual setting and the hospital discharge will be decided by pulmonologists according to the usual criteria

FreeDom

FreeDom strategy (early discharge, automated weaning at home, telemedicine, telereadaptation):

-initial conventional hospitalization before discharge home, O2 flow rate automatically titrated by FreeO2 (based on a SpO2 target). The hospital discharge will be possible if the definite criteria are met.

After hospital discharge, patient will have home hospitalisation. Automated oxygen flow titration, patient education will be conducted for using the telemedicine system, for questionnaires and for the tele-rehabilitation program will be initiated for home hospitalization,

Group Type ACTIVE_COMPARATOR

FreeDom

Intervention Type DEVICE

Early return home, patients using an innovative device that automatically adjusts and wean the oxygen flow (FreeO2 system) coupled to telemedicine and tele-rehabilitation

Interventions

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Control

The hospitalization will take place in the usual setting and the hospital discharge will be decided by pulmonologists according to the usual criteria

Intervention Type OTHER

FreeDom

Early return home, patients using an innovative device that automatically adjusts and wean the oxygen flow (FreeO2 system) coupled to telemedicine and tele-rehabilitation

Intervention Type DEVICE

Other Intervention Names

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Usual oxygen administration and usual hospitalization Early Hospital discharge with home hospitalisation

Eligibility Criteria

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Inclusion Criteria

All patients hospitalized for COPD exacerbation for less than 48 hours will be considered.

* known or suspected COPD to entry
* Age \> or = 40 years
* Ex-smoker history (10 pack / year or more)
* Acute Exacerbation: dyspnea of recent onset (less than 15 days)
* The need for oxygen therapy with a moderate rate: \<6L / min to maintain SpO2 \> 90% (for oxygen dependent patient, the oxygen flow must be higher than flow at home)

Exclusion Criteria

* Refusal to consent to participate in the study,
* Indication for an imminent intubation according to the pulmonologist,
* Sleep Apnea
* NIV used at home
* Lack of FreeO2 system available at the time of randomization
* Non-autonomous and alone at home
* Patient alone at home
* Patients who live more than 50 km from the hospital
* Patient already included in the study within 3 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Laval University

OTHER

Sponsor Role lead

Responsible Party

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François Lellouche

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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François Lellouche

Role: PRINCIPAL_INVESTIGATOR

Laval University

Locations

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Institut Universitaire de Cardiologie et de Pneumologie de Québec

Québec, , Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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François Lellouche

Role: CONTACT

418-656-8711 ext. 3572

Pierre-alexandre Bouchard

Role: CONTACT

418-656-8711 ext. 2712

Facility Contacts

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Francois Lellouche

Role: primary

Other Identifiers

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21419

Identifier Type: -

Identifier Source: org_study_id

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